REVENUE - Disaggregation of Revenue (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Disaggregation of Revenue [Line Items]
Total Revenues	$ 46,385	$ 42,518	$ 26,145
Net product sales
Disaggregation of Revenue [Line Items]
Total Revenues	45,055	41,321	25,174
Other revenues
Disaggregation of Revenue [Line Items]
Total Revenues	614	582	374
Alliance revenues
Disaggregation of Revenue [Line Items]
Total Revenues	11,556	9,979	10,541
Alliance revenues | Net product sales
Disaggregation of Revenue [Line Items]
Total Revenues	10,840	9,364	9,944
Alliance revenues | Alliance revenues
Disaggregation of Revenue [Line Items]
Total Revenues	$ 716	$ 615	$ 597