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REVENUE REVENUE (Tables)
 12 Months Ended
Dec. 31, 2021
Revenue from Contract with Customer [Abstract]  
Disaggregation of Revenue
The following table summarizes the disaggregation of revenue by nature:
 Year Ended December 31,
Dollars in Millions202120202019
Net product sales$45,055 $41,321 $25,174 
Alliance revenues716 615 597 
Other revenues614 582 374 
Total Revenues$46,385 $42,518 $26,145 
Schedule of Revenue by Major Customers
Gross revenue to the three largest pharmaceutical wholesalers in the U.S. as a percentage of global gross revenues was as follows:
 Year Ended December 31,
 202120202019
McKesson Corporation32 %31 %26 %
AmerisourceBergen Corporation25 %25 %20 %
Cardinal Health, Inc.20 %19 %17 %
Reconciliation of Gross Product Sales to Net Product Sales
The following table summarizes GTN adjustments:
 Year Ended December 31,
Dollars in Millions202120202019
Gross product sales$67,897 $60,016 $37,206 
GTN adjustments(a)
Charge-backs and cash discounts(7,253)(5,827)(3,675)
Medicaid and Medicare rebates(9,374)(7,595)(4,941)
Other rebates, returns, discounts and adjustments(6,215)(5,273)(3,416)
Total GTN adjustments(22,842)(18,695)(12,032)
Net product sales$45,055 $41,321 $25,174 
(a)    Includes adjustments for provisions for product sales made in prior periods resulting from changes in estimates of $319 million in 2021, $106 million in 2020 and $132 million in 2019.
Disaggregation of Revenue by Product and Region
The following table summarizes the disaggregation of revenue by product and region:
 Year Ended December 31,
Dollars in Millions202120202019
Revlimid$12,821 $12,106 $1,299 
Eliquis10,762 9,168 7,929 
Opdivo7,523 6,992 7,204 
Pomalyst/Imnovid3,332 3,070 322 
Orencia3,306 3,157 2,977 
Sprycel2,117 2,140 2,110 
Yervoy2,026 1,682 1,489 
Abraxane1,181 1,247 166 
Reblozyl551 274 — 
Empliciti334 381 357 
Abecma164 — — 
Zeposia134 12 — 
Breyanzi87 — — 
Inrebic74 55 5 
Onureg73 17 — 
Mature and other brands1,900 2,217 2,287 
Total Revenues$46,385 $42,518 $26,145 
United States$29,214 $26,577 $15,342 
Europe10,687 9,853 6,266 
Rest of World5,632 5,457 4,013 
Other(a)
852 631 524 
Total Revenues$46,385 $42,518 $26,145 
(a)    Other revenues include royalties and alliance-related revenues for products not sold by BMS’s regional commercial organizations.