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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Collaboration Agreements - Additional Information (Details) - USD ($)	1 Months Ended	12 Months Ended
	Sep. 30, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Jul. 17, 2020
Research And Development Arrangement Contract To Perform For Others [Line Items]
Collaboration revenue			$ 6,254,000
Contract liability/deferred revenue		$ 2,733,000	2,733,000	$ 8,987,000
Contract with customer, liability, noncurrent		2,733,000	2,733,000
Research and development expense		69,980,000	68,524,000
BeiGene Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Collaboration revenue				$ 6,300,000
Agreed to pay maximum amount development and regulatory costs		45,000,000.0
Upfront cash payment received		40,000,000.0
Contract with customer, liability, noncurrent		2,700,000	2,700,000
Research and development expense		0	0
Incremental costs		3,500,000
BeiGene Agreement \| Other Assets
Research And Development Arrangement Contract To Perform For Others [Line Items]
Incremental costs		200,000	200,000
BeiGene Agreement \| Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Potential milestone payments	$ 285,000,000.0	500,000,000.0
BeiGene Agreement \| Development and Regulatory \| Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Potential milestone payments	65,000,000.0	113,800,000
BeiGene Agreement \| Sales Milestone Payments \| Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Potential milestone payments	$ 220,000,000.0	385,000,000.0
Bei Gene Limited
Research And Development Arrangement Contract To Perform For Others [Line Items]
Contract liability/deferred revenue					$ 40,000,000.0
Arbutus Biopharma Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development expense		2,700,000	$ 2,000,000.0
Antios Agreement
Research And Development Arrangement Contract To Perform For Others [Line Items]
Research and development expense		$ 400,000