CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit
Balance at Dec. 31, 2020	$ 240,578	$ 34	$ 742,387	$ (270)	$ (501,573)
Balance (in shares) at Dec. 31, 2020		34,026,680
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs	52,806	$ 11	52,795
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs (in shares)		11,234,207
Issuance of common stock under Employee Stock Purchase Plan (ESPP)	258		258
Issuance of common stock under Employee Stock Purchase Plan (ESPP) (in shares)		88,820
Issuance of common stock for settlement of restricted stock units (RSUs)		$ 1	(1)
Issuance of common stock for settlement of restricted stock units (RSUs) (in shares)		347,096
Issuance of common stock upon cashless exercise of pre-funded warrants		$ 2	(2)
Issuance of common stock upon cashless exercise of pre-funded warrants (in shares)		2,423,634
Unrealized loss on marketable debt securities	(149)			(149)
Stock-based compensation	5,291		5,291
Net loss	(129,855)				(129,855)
Balance at Dec. 31, 2021	168,929	$ 48	800,728	(419)	(631,428)
Balance (in shares) at Dec. 31, 2021		48,120,437
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs	325	$ 1	324
Issuance of common stock under at-the-market (ATM) equity offering program, net of issuance costs (in shares)		300,827
Issuance of common stock under Employee Stock Purchase Plan (ESPP)	289		289
Issuance of common stock under Employee Stock Purchase Plan (ESPP) (in shares)		225,832
Issuance of common stock for settlement of restricted stock units (RSUs) (in shares)		247,877
Unrealized loss on marketable debt securities	(384)			(384)
Stock-based compensation	6,597		6,597
Net loss	(93,092)				(93,092)
Balance at Dec. 31, 2022	$ 82,664	$ 49	$ 807,938	$ (803)	$ (724,520)
Balance (in shares) at Dec. 31, 2022		48,894,973