Commitments and Contingencies - Additional Information (Detail) $ / shares in Units, $ in Thousands			1 Months Ended		12 Months Ended		156 Months Ended	168 Months Ended
	Mar. 26, 2021 ft²	Feb. 06, 2015 shares	Mar. 31, 2018 USD ($) $ / shares shares	Jun. 30, 2013 shares	Dec. 31, 2023 USD ($) Milestone	Dec. 31, 2022 USD ($) Milestone	Dec. 31, 2022 USD ($)	Dec. 31, 2023 USD ($)	Aug. 16, 2021 ft²	Feb. 28, 2010 USD ($)
Other Commitments [Line Items]
Lease expiration date	Mar. 31, 2023
Operating lease, right-of-use asset						$ 40	$ 40
Operating lease, liability						48	48
Non-cancellable purchase obligations					$ 2,312			$ 2,312
Contract obligation, prepaid amount					1,432			1,432
Operating Lease Agreements [Member]
Other Commitments [Line Items]
Area of land | ft²									6,455
Harvard and Dana-Farber Agreement [Member]
Other Commitments [Line Items]
Milestone payments					$ 0	$ 0
Milestones achieved | Milestone					0	0
Additional liabilities for milestone payments					$ 0	$ 0	0	0
Non-refundable cash payment							$ 5,118	5,153
Harvard and Dana-Farber Agreement [Member] | Therapeutic Product [Member]
Other Commitments [Line Items]
Aggregate milestones payments										$ 7,700
Harvard and Dana-Farber Agreement [Member] | Diagnostic Product [Member]
Other Commitments [Line Items]
Aggregate milestones payments										$ 700
Harvard and Dana-Farber Agreement [Member] | License and Maintenance [Member]
Other Commitments [Line Items]
Annual license maintenance fees					110
Harvard and Dana-Farber Agreement [Member] | License [Member]
Other Commitments [Line Items]
Annual license maintenance fees					35	110
Umicore Agreement [Member]
Other Commitments [Line Items]
Milestone payments					$ 0	0
Milestones achieved | Milestone					0
Additional liabilities for milestone payments					$ 0			$ 0
Umicore Agreement [Member] | License [Member]
Other Commitments [Line Items]
Annual license maintenance fees					$ 50	$ 50
UTHSCT Agreement [Member] | Common Stock [Member]
Other Commitments [Line Items]
Shares granted in consideration | shares		4,000,000		2,000,000
UTHSCT Agreement [Member] | Non-convertible preferred stock [Member]
Other Commitments [Line Items]
Shares granted in consideration | shares		400,000		400,000
Vivarta Therapeutics LLC [Member]
Other Commitments [Line Items]
License fee on agreement effective date			$ 10,000
License fee on receipt of positive freedom to operate analysis from legal counsel			$ 40,000
Vivarta Therapeutics LLC [Member] | Common Stock [Member]
Other Commitments [Line Items]
Issuance of Common Stock Warrant | shares			75,000
Warrant per share | $ / shares			$ 0.12
Boston, Massachusetts [Member] | Operating Lease Agreements [Member] | 285 Summer Street [Member]
Other Commitments [Line Items]
Area of land | ft²	3,365