Nature of the Business and Basis of Presentation - Additional Information (Detail) $ in Thousands		3 Months Ended	12 Months Ended
	Nov. 10, 2022 shares	Mar. 31, 2023 Employees	Dec. 31, 2022 USD ($) Employees shares	Nov. 09, 2022 shares	Dec. 31, 2021 USD ($) shares	Jun. 16, 2021 shares	Dec. 31, 2020 shares
Class of Stock [Line Items]
Proceeds from collaboration agreement			$ 34,910
Cash, cash equivalents and investments			21,242
Accumulated deficit			$ (272,785)		$ (245,456)
Workforce reduction, remaining number of employees | Employees			9
Common stock, shares authorized | shares	15,000,000		45,000,000	300,000,000	15,000,000	15,000,000	7,500,000
Reverse stock split, description	On November 10, 2022, the Company effected a one-for-twenty reverse stock split on its common stock (the “Reverse Stock Split”). The Reverse Stock Split was reflected on the Nasdaq Capital Market beginning with the opening of trading on November 11, 2022. Pursuant to the Reverse Stock Split, every 20 shares of the Company's issued and outstanding shares of common stock were automatically combined into one issued and outstanding share of common stock, without any change in the par value per share of the common stock. The Reverse Stock Split reduced the authorized number of shares of common stock from 300,000,000 to 15,000,000 and, pursuant to the certificate of amendment, such reduced authorized number of shares of common stock was subsequently multiplied by three, such that following the Reverse Stock Split the Company has 45,000,000 shares of common stock authorized. The Reverse Stock Split affected all issued and outstanding shares of the Company's common stock, and the respective numbers of shares of common stock underlying the Company’s outstanding stock options, outstanding warrants and the Company's equity incentive plans were proportionately adjusted. All share and per share amounts of the common stock included in the accompanying consolidated financial statements have been retrospectively adjusted to give effect to the Reverse Stock Split for all periods presented.
Reverse stock split conversion ratio	0.05
Forecast [Member]
Class of Stock [Line Items]
Workforce reduction, remaining number of employees | Employees		3
Common Stock [Member]
Class of Stock [Line Items]
Proceeds from sales of stock			$ 145,467
Preferred Stock [Member]
Class of Stock [Line Items]
Proceeds from sales of stock			$ 131,211