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                          September 30, 2022

       Jeffrey Frelick
       Chief Executive Officer
       Bone Biologics Corporation
       2 Burlington Woods Drive, Suite 100
       Burlington, MA 01803

                                                        Re: Bone Biologics
Corporation
                                                            Registration
Statement on Form S-1
                                                            Filed September 23,
2022
                                                            File No. 333-267588

       Dear Mr. Frelick:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Tyler
Howes at 202-551-3370 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              David Ficksman, Esq.