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                           July 2, 2021

       Jeffrey Frelick
       Chief Executive Officer
       Bone Biologics Corporation
       2 Burlington Woods Drive, Suite 100
       Burlington, MA 01803

                                                        Re: Bone Biologics
Corporation
                                                            Registration
Statement on Form S-1
                                                            Filed June 28, 2021
                                                            File No. 333-257484

       Dear Mr. Frelick:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Irene
Paik at 202-551-6553 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              David L. Ficksman