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Certain Financial Statement Caption Information - Components of Accrued Liabilities (Details) - USD ($)
$ in Thousands
Mar. 31, 2018
Dec. 31, 2017
Balance Sheet Related Disclosures [Abstract]    
Clinical trial expenses $ 3,955 $ 2,809
Payroll and other employee-related expenses 1,346 2,489
Contract manufacturing services 1,310 1,536
Professional fees 246 276
Contract research services 136 104
Interest payable 65 77
Other 802 829
Total accrued liabilities $ 7,860 $ 8,120