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Common Stock, Convertible Preferred Stock and Stockholders' Deficit - Schedule of Changes in Number of Convertible Preferred and Common Stock Outstanding and Total Stockholders' Deficit (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Class Of Stock [Line Items]    
Balance, December 31, 2016 $ (124,417)  
Stock-based compensation 529  
Exercise of stock options 41  
Other comprehensive loss (1)  
Net loss (9,073) $ (8,006)
Balance, March 31, 2017 $ (132,921)  
Convertible Preferred Stock    
Class Of Stock [Line Items]    
Balance, December 31, 2016, shares 46,163,605  
Balance, March 31, 2017, shares 46,163,605  
Shares of Common Stock    
Class Of Stock [Line Items]    
Balance, December 31, 2016, shares 2,202,517  
Exercise of stock options, shares 24,648  
Fractional shares adjustment upon reverse stock split, shares 2  
Balance, March 31, 2017, shares 2,227,167