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Note 13 - Stock-based Compensation (Details Textual) - USD ($)
3 Months Ended 9 Months Ended 12 Months Ended
Jun. 16, 2016
Nov. 01, 2010
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Dec. 31, 2015
Stock Incentive Plan [Member] | Employee Stock Option [Member]                  
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period   4 years              
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period   10 years              
Stock Incentive Plan [Member] | Two Medical Advisory Board Members [Member]                  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross 3,300,000                
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price $ 0.04                
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value $ 0.0335                
Allocated Share-based Compensation Expense $ 110,550                
Stock Incentive Plan [Member]                  
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized     12,500,000       12,500,000   12,500,000
Allocated Share-based Compensation Expense     $ 0     $ 96,323 $ 116,550 $ 146,385  
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Lower Range Limit             $ 0.04   $ 0.11
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Upper Range Limit             $ 2   $ 2
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value     $ 569,500       $ 569,500   $ 0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term             7 years 138 days   7 years 167 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross     3,300,000        
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price     $ 0.04