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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 wuE4+hZcBSUk9JLeuXFv8Q==

<SEC-DOCUMENT>0001042167-09-000191.txt : 20091106
<SEC-HEADER>0001042167-09-000191.hdr.sgml : 20091106
<ACCEPTANCE-DATETIME>20091105174319
ACCESSION NUMBER:		0001042167-09-000191
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20091106
DATE AS OF CHANGE:		20091105
EFFECTIVENESS DATE:		20091106

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CytoPherx, Inc.
		CENTRAL INDEX KEY:			0001416127
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-110172
		FILM NUMBER:		091162248

	BUSINESS ADDRESS:	
		STREET 1:		401 WEST MORGAN ROAD
		CITY:			Ann Arbor
		STATE:			MI
		ZIP:			48108
		BUSINESS PHONE:		(734) 662-7667

	MAIL ADDRESS:	
		STREET 1:		401 WEST MORGAN ROAD
		CITY:			Ann Arbor
		STATE:			MI
		ZIP:			48108

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Nephrion Inc
		DATE OF NAME CHANGE:	20071025
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0603</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001416127</cik>
        <entityName>CytoPherx, Inc.</entityName>
        <issuerAddress>
            <street1>401 WEST MORGAN ROAD</street1>
            <city>Ann Arbor</city>
            <stateOrCountry>MI</stateOrCountry>
            <zipCode>48108</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(734) 272-4772</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>Nephrion Inc</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2007</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>R.</firstName>
                <middleName>James</middleName>
                <lastName>Danehy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>401 West Morgan Road</street1>
                <city>Ann Arbor</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mark</firstName>
                <middleName>R.</middleName>
                <lastName>Morsfield</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>401 West Morgan Road</street1>
                <city>Ann Arbor</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>H.</firstName>
                <middleName>David</middleName>
                <lastName>Humes</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>401 West Morgan Road</street1>
                <city>Ann Arbor</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Hugo</firstName>
                <lastName>Braun</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>401 West Morgan Road</street1>
                <city>Ann Arbor</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Mina</firstName>
                <middleName>Patel</middleName>
                <lastName>Sooch</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>401 West Morgan Road</street1>
                <city>Ann Arbor</city>
                <stateOrCountry>MI</stateOrCountry>
                <zipCode>48108</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-10-23</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>235294</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>2000000</totalOfferingAmount>
            <totalAmountSold>2000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>5</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CytoPherx, Inc.</issuerName>
                <signatureName>/s/ Mark R. Morsfield</signatureName>
                <nameOfSigner>Mark R. Morsfield</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2009-11-02</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----