UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No.     )*

AMPIO PHARMACEUTICALS, INC.

(Name of Issuer)

COMMON STOCK, PAR VALUE $0.0001 PER SHARE

(Title of Class of Securities)

03209T 10 9

(CUSIP Number)

December 31, 2011

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

¨ Rule 13d-1(b)

¨ Rule 13d-1(c)

x Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 03209T 10 9 13G Page 2 of 5

1.	NAMES OF REPORTING PERSONS David Bar-Or, M.D.
2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (a)  ¨        (b)  ¨
3.	SEC USE ONLY
4.	CITIZENSHIP OR PLACE OF ORGANIZATION United States
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5.	SOLE VOTING POWER - 3,166,667(1) -
		6.	SHARED VOTING POWER - 0 -
		7.	SOLE DISPOSITIVE POWER - 3,166,667(1) -
		8.	SHARED DISPOSITIVE POWER - 0 -
9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 3,166,667(1)
10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES    ¨ N/A
11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 9.2%(2)
12.	TYPE OF REPORTING PERSON IN

(1) Includes 466,667 shares of common stock which Dr. Bar-Or has the right to acquire through the exercise of stock options. Excludes 1,025,000 shares of common stock owned of record by Raphael Bar-Or, Dr. Bar-Or’s son, as to which Dr. Bar-Or disclaims beneficial ownership.

(2) The percentage is calculated based on 31,081,434 shares of common stock outstanding on December 31, 2011.

CUSIP No. 03209T 10 9 13G Page 3 of 5

Item 1(a). Name of Issuer:

Ampio Pharmaceuticals, Inc. (the “Issuer”)

Item 1(b). Address of Issuer’s Principal Executive Offices:

Ampio Pharmaceuticals, Inc.

5445 DTC Parkway, Suite 925

Greenwood Village, CO 80111

Item 2(a). Name of Persons Filing:

This statement is filed on behalf of David Bar-Or, M.D., an individual.

Item 2(b). Address of Principal Business Office or, if None, Residence:

The address of the principal business office of the Reporting Person is:

5445 DTC Parkway, Suite 925

Greenwood Village, CO 80111

Item 2(c). Citizenship:

United States.

Item 2(d). Title of Class of Securities:

Common Stock, par value $0.0001 per share.

Item 2(e). CUSIP Number:

03209T 10 9

Item 3.

If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a) ¨    Broker or dealer registered under Section 15 of the Act;

(b) ¨    Bank as defined in Section 3(a)(6) of the Act;

(c) ¨    Insurance company as defined in Section 3(a)(19) of the Act;

(d) ¨    Investment company registered under Section 8 of the Investment Company Act of 1940;

(e) ¨    An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);

(f) ¨    An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);

(g) ¨    A parent holding company or control person in accordance with §240.13d-1 (b)(1)(ii)(G);

(h) ¨    A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;

(i) ¨    A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the         Investment Company Act;

(j) ¨    A non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J);

(k) ¨    Group, in accordance with §240.13d-1(b)(1)(ii)(K).

If filing as a non-U.S. institution in accordance with §240.13(d)-1(b)(1)(ii)(J), please specify the type of institution:                                          .

CUSIP No. 03209T 10 9 13G Page 4 of 5

Item 4. Ownership.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a) Amount beneficially owned: 3,166,667

(b) Percent of class: 9.2%

(c) Number of shares as to which such person has:

(i) Sole power to vote or to direct the vote: 3,166,667

(ii) Shared power to vote or to direct the vote: –0 –

(iii) Sole power to dispose or to direct the disposition of: 3,166,667

(iv) Shared power to dispose or to direct the disposition of: –0 –

Item 5. Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following  ¨.

Item 6. Ownership of More than Five Percent on Behalf of Another Person.

Not applicable.

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

Not applicable.

Item 8. Identification and Classification of Members of the Group.

Not applicable.

Item 9. Notice of Dissolution of Group.

Not applicable.

Item 10. Certification.

Not applicable.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Date: February 13, 2012	/s/    David Bar-Or
	David Bar-Or, M.D.