Organization and Basis of Presentation (Details)			3 Months Ended
	Mar. 01, 2024 employee	Aug. 04, 2023	Mar. 31, 2024 USD ($)	Mar. 31, 2023 USD ($)	Jan. 01, 2024	Dec. 31, 2023 USD ($)
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Reverse stock split, conversion ratio		0.1
Cash and cash equivalents			$ 15,759,000	$ 4,104,000		$ 17,948,000
Short term investments			12,561,000			48,823,000
Restricted cash and cash equivalents and restricted short-term investments			24,800,000
Accumulated deficit			612,630,000			581,208,000
Net cash used in operating activities			28,131,000	32,413,000
Convertible notes payable (at fair value)			29,080,000			69,803,000
Impairment of intangible assets			448,000	$ 0
Inventories non-current (included in other long-term assets)			4,215,000			$ 4,710,000
Depreciable lives | Saphyr and Stratys Instruments
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Property and equipment useful life					7 years	5 years
Reduction in depreciation expense			(500,000)
Workforce Reduction
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Restructuring, expected number of positions eliminated | employee	120
Convertible notes payable
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Convertible notes payable (at fair value)			29,100,000
Redemption, outstanding amount			$ 24,300,000
Redemption price, percentage of principal amount redeemed (as a percent)			115.00%
Redemption amount, remainder of fiscal year			$ 28,000,000
Retirement fee			$ 2,200,000