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Condensed Consolidated Statements of Changes in Stockholders’ Equity (Unaudited) - USD ($)
Common Stock
Preferred Stock – Series C-3, Series E and Series G
Accumulated Other Comprehensive Income (Loss)
Additional Paid-in Capital
Accumulated Deficit
Total
Balance at Dec. 31, 2020 $ 33,558 $ 242 $ 102,006 $ 261,536,061 $ (217,448,855) $ 44,223,012
Balance (in Shares) at Dec. 31, 2020 33,558,096 241,623        
Stock issued in connection with warrants exercised, cash $ 31 164,855 164,886
Stock issued in connection with warrants exercised, cash (in Shares) 31,407          
Stock issued in connection with warrants exercised, cashless $ 70 (70)
Stock issued in connection with warrants exercised, cashless (in Shares) 70,269          
Stock issued in connection with options exercised $ 33 137,002 137,035
Stock issued in connection with options exercised (in Shares) 32,734          
Conversion of Series G preferred shares to common stock $ 556 $ (10) (546)
Conversion of Series G preferred shares to common stock (in Shares) 556,069 (10,001)        
Conversion of Series C-3 preferred shares to common stock $ 100 $ (50) (50)
Conversion of Series C-3 preferred shares to common stock (in Shares) 100,000 (50,000)        
Stock issued in connection with ATM sale of common stock, net $ 3,738 41,451,892 41,455,630
Stock issued in connection with ATM sale of common stock, net (in Shares) 3,737,862          
Stock-based compensation 2,741,680 2,741,680
Other comprehensive income (loss) (2,825) (2,825)
Net loss (11,849,873) (11,849,873)
Balance at Jun. 30, 2021 $ 38,086 $ 182 99,181 306,030,824 (229,298,728) 76,869,545
Balance (in Shares) at Jun. 30, 2021 38,086,437 181,622        
Balance at Mar. 31, 2021 $ 38,046 $ 182 98,826 304,843,806 (224,665,793) 80,315,067
Balance (in Shares) at Mar. 31, 2021 38,046,092 181,622        
Stock issued in connection with warrants exercised, cash $ 7 39,950 39,957
Stock issued in connection with warrants exercised, cash (in Shares) 7,611          
Stock issued in connection with options exercised $ 33 137,002 137,035
Stock issued in connection with options exercised (in Shares) 32,734          
Stock-based compensation 1,010,066 1,010,066
Other comprehensive income (loss) 355 355
Net loss (4,632,935) (4,632,935)
Balance at Jun. 30, 2021 $ 38,086 $ 182 99,181 306,030,824 (229,298,728) 76,869,545
Balance (in Shares) at Jun. 30, 2021 38,086,437 181,622        
Balance at Dec. 31, 2021 $ 38,086 $ 182 87,130 308,331,750 (245,659,081) 62,798,067
Balance (in Shares) at Dec. 31, 2021 38,086,437 181,622        
Stock issued in connection with ATM sale of common stock, net $ 3,021 11,412,351 11,415,372
Stock issued in connection with ATM sale of common stock, net (in Shares) 3,020,340          
Stock-based compensation 2,211,945 2,211,945
Other comprehensive income (loss) (47,611) (47,611)
Net loss (14,639,033) (14,639,033)
Balance at Jun. 30, 2022 $ 41,107 $ 182 39,519 321,956,046 (260,298,114) 61,738,740
Balance (in Shares) at Jun. 30, 2022 41,106,777 181,622        
Balance at Mar. 31, 2022 $ 38,728 $ 182 49,921 312,473,623 (252,693,275) 59,869,179
Balance (in Shares) at Mar. 31, 2022 38,727,979 181,622        
Stock issued in connection with ATM sale of common stock, net $ 2,379 8,408,777 8,411,156
Stock issued in connection with ATM sale of common stock, net (in Shares) 2,378,798          
Stock-based compensation 1,073,646 1,073,646
Other comprehensive income (loss) (10,402) (10,402)
Net loss (7,604,839) (7,604,839)
Balance at Jun. 30, 2022 $ 41,107 $ 182 $ 39,519 $ 321,956,046 $ (260,298,114) $ 61,738,740
Balance (in Shares) at Jun. 30, 2022 41,106,777 181,622