LIMITED POWER OF ATTORNEY

      KNOW ALL BY THESE PRESENTS, that the undersigned hereby constitutes and
appoints Jonathan Drachman, Robert Ho and Kris McGrew, as long as they are
providing services to Neoleukin Therapeutics, Inc. ("Company"), and each of
them, as his true and lawful attorney-in-fact to:

     (1)	execute for and on behalf of the undersigned, in the undersigned's
capacity as an officer and/or director of the Company, any and all Form 3, 4 or
5 reports required to be filed by the undersigned in accordance with Section
16(a) of the Securities Exchange Act of 1934, as amended ("Exchange Act"), and
the rules and regulations thereunder with respect to transactions in securities
of the Company;

     (2)	do and perform any and all acts for and on behalf of the undersigned
which may be necessary or desirable to complete and execute any such Form 3, 4
or 5 report and timely file such report with the U.S. Securities and Exchange
Commission and any stock exchange or similar authority; and

     (3)	take any other action of any type whatsoever in connection with the
foregoing which, in the opinion of such attorney in-fact, may be of benefit to,
in the best interest of, or legally required by, the undersigned, it being
understood that the documents executed by such attorney in-fact on behalf of the
undersigned, pursuant to this Power of Attorney, shall be in such form and shall
contain such terms and conditions as such attorney-in-fact may approve in his
discretion.

     The undersigned hereby grants to such attorney-in-fact full power and
authority to do and perform each and every act and thing whatsoever requisite,
necessary and proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could do if personally present, with full power of substitution or revocation,
hereby ratifying and confirming all that such attorney-in-fact, or her/his
substitute or substitutes, shall lawfully do or cause to be done by virtue of
this Power of Attorney and the rights and powers herein granted.  The
undersigned acknowledges that no such attorney in-fact, in serving in such
capacity at the request of the undersigned, is hereby assuming, nor is the
Company hereby assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Exchange Act.

  The undersigned agrees that such attorney-in-fact may rely entirely on
information furnished orally or in writing by the undersigned to each such
attorney-in-fact. The undersigned further agrees that each attorney-in-fact and
the Company are not responsible for any errors or omissions in such filings. The
attorneys-in-fact and the Company are not responsible for determining whether or
not the transactions reported could be matched with any other transactions for
the purpose of determining liability for short-swing profits under Section
16(b).

     This Power of Attorney shall remain in full force and effect until the
undersigned is no longer required to file Form 3, 4 or 5 reports with respect to
the undersigned's holdings of and transactions in securities issued by the
Company, unless earlier revoked by the undersigned in a signed writing delivered
to the foregoing attorneys-in-fact.

     IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be
executed as of the 1st day of October, 2020.

/s/ Holly Vance
Holly Vance