Restructuring (Tables)

12 Months Ended

Dec. 31, 2018

Restructuring Plan, July 2018 [Member]

Summary of Total Amount Expected to Be Incurred and Liability

The following table shows the total amount expected to be incurred and the liability related to the July 2018 restructuring as at December 31, 2018:

(in thousands)	CLINICAL TRIAL CLOSING COSTS			ONE-TIME EMPLOYEE TERMINATION BENEFITS			CONTRACT TERMINATION COSTS			SAN BRUNO OFFICE CLOSING COSTS			TOTAL EXPENSES
Amounts accrued as at January 1, 2018	$	—		$	—		$	—		$	—		$	—
Charges for the year		5,703			1,879			1,108			465			9,155
Revised estimates during the year		41			2			187			5			235
Total restructuring costs expected to be incurred		5,744			1,881			1,295			470			9,390
Amounts paid during the year		(2,204	)		(1,881	)		(1,201	)		(470	)		(5,756	)
Amounts accrued at December 31, 2018	$	3,540		$	—		$	94		$	—		$	3,634

Restructuring Plan, November 2018 [Member]

Summary of Total Amount Expected to Be Incurred and Liability

The following table shows the total amount expected to be incurred and the liability related to the November 2018 restructuring as at December 31, 2018:

(in thousands)	ONE-TIME EMPLOYEE TERMINATION BENEFITS
Total restructuring costs expected to be incurred	$	984
Amounts paid during the year		(922	)
Amounts accrued at December 31, 2018	$	62