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Stock-Based Compensation - Additional Information (Details)
12 Months Ended
May 11, 2017
May 09, 2017
Dec. 31, 2017
USD ($)
Plan
$ / shares
shares
Dec. 31, 2016
USD ($)
$ / shares
shares
Dec. 31, 2015
$ / shares
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of stock compensation plans | Plan     2    
Common stock reverse stock split ratio     0.111111111    
Common stock reverse stock split description     one for nine    
Number of options issued     595,800 13,054  
Number of options outstanding     682,200 59,777 63,627
Range of exercise prices | $ / shares     $ 6.65 $ 18.45 $ 17.70
Aggregate intrinsic value of options exercised | $     $ 0 $ 2,100  
Unrecognized stock-based compensation expense | $     $ 2,300,000    
Unrecognized stock-based compensation expense, recognized over estimated weighted average period     2 years 6 months    
Stock-based compensation expense | $     $ 579,000 $ 171,000  
Performance-based Option [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock-based compensation expense | $     $ 80,000    
Minimum [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Range of exercise prices | $ / shares     $ 4.21    
Maximum [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Range of exercise prices | $ / shares     $ 19.75    
2014 Stock Incentive Plan [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of additional grants made from the plan     3,617,376    
Options granted, expiration period     10 years    
Common stock, shares authorized for issuance     1,700,000    
Maximum annual increase in common stock reserved for future issuance     1,800,000    
Additional shares of common stock, percentage     400.00%    
2007 Stock Incentive Plan [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Options granted, expiration period     10 years    
Number of options issued     0    
Number of options outstanding     0    
Otic Pharma [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of stock compensation plans | Plan     1    
Common stock reverse stock split description     One-for-nine    
Tokai Pharmaceuticals, Inc. [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock reverse stock split description one-for-nine        
Tokai Pharmaceuticals, Inc. [Member] | 2012 Global Share Incentive Plan [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Number of additional grants made from the plan     0    
Options granted, expiration period     10 years    
Reverse Stock-Split [Member] | Otic Pharma [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock reverse stock split ratio 0.111111111 0.111111111      
Reverse Stock-Split [Member] | Tokai Pharmaceuticals, Inc. [Member]          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Common stock reverse stock split ratio 0.111111111