Stockholders' Equity - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Millions			12 Months Ended
	Jan. 11, 2022	Sep. 21, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Mar. 31, 2021
Class Of Stock [Line Items]
Preferred stock, par value			$ 0.001	$ 0.001
Warrant exercise price per share			$ 0.001
Common Stock [Member]
Class Of Stock [Line Items]
Warrants available for exercise			1,145,631
Series X1 Preferred Stock [Member]
Class Of Stock [Line Items]
Shares of common stock issued upon conversion of each share of preferred stock			2,789,301
Warrants available for exercise			50,207.419
Series X1 Non-voting Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Preferred stock, par value			$ 0.001	$ 0.001
Jeffries LLC [Member] | ATM Program [Member]
Class Of Stock [Line Items]
Common stock number of shares issued			0	0
Equity distribution agreement maximum value of common shares issuable						$ 75.0
Public float minimum balance to be maintained			$ 75.0
Jeffries LLC [Member] | Maximum [Member] | ATM Program [Member]
Class Of Stock [Line Items]
Equity distribution agreement maximum value of common shares issuable			$ 10.5
Series X Exchange Agreement [Member] | BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Common Stock [Member]
Class Of Stock [Line Items]
Conversion of stock, shares converted					344,666
Series X Exchange Agreement [Member] | BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Series X Non-voting Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Conversion of stock, shares issued					6,203.98
Series X1 Exchange Agreement [Member] | BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Common Stock [Member]
Class Of Stock [Line Items]
Conversion of stock, shares converted	550,000
Series X1 Exchange Agreement [Member] | BVF Exchanging Stockholders, Series X Exchanging Stockholders [Member] | Series X1 Non-voting Convertible Preferred Stock [Member]
Class Of Stock [Line Items]
Conversion of stock, shares issued	9,899.99
Warrant Exchange Agreement and Exchange Agreements [Member] | BVF Exchanging Stockholders | Common Stock [Member]
Class Of Stock [Line Items]
Warrants to purchase common stock					509,117
September 2021 Warrant Exchange Agreement [Member] | Common Stock [Member]
Class Of Stock [Line Items]
Warrants issued		298,692
September 2021 Warrant Exchange Agreement [Member] | Series X1 Non-voting Convertible Preferred Stock [Member] | Common Stock [Member]
Class Of Stock [Line Items]
Warrants exercisable for exchange		5,376.456