Mailing Address: PO Box 9431 Stn Prov Govt Victoria BC V8W 9V3 www.corporateonline.gov.bc.ca Location: 2nd Floor - 940 Blanshard Street Victoria BC 1 877 526-1526 Notice of Articles BUSINESS CORPORATIONS ACT CERTIFIED COPY Of a Document filed with the Province of British Columbia Registrar of Companies CAROL PREST This Notice of Articles was issued by the Registrar on: January 26, 2022 11:16 AM Pacific Time Incorporation Number: C1117210 Recognition Date and Time: Continued into British Columbia on May 2, 2017 09:30 AM Pacific Time NOTICE OF ARTICLES Name of Company: ZYMEWORKS INC. REGISTERED OFFICE INFORMATION Mailing Address: SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 CANADA Delivery Address: SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 CANADA RECORDS OFFICE INFORMATION Mailing Address: SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 CANADA Delivery Address: SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 CANADA Page: 1 of 3

DIRECTOR INFORMATION Last Name, First Name, Middle Name: Sacks, Natalie Mailing Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Delivery Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Last Name, First Name, Middle Name: Hillan, Kenneth J. Mailing Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Delivery Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Last Name, First Name, Middle Name: Galbraith, Kenneth Mailing Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Delivery Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Last Name, First Name, Middle Name: Renton, Hollings C, Mailing Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Delivery Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Last Name, First Name, Middle Name: Mahony, Susan Mailing Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Delivery Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Last Name, First Name, Middle Name: Zoth, Lota Mailing Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Delivery Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Page: 2 of 3

Last Name, First Name, Middle Name: Cox, Troy Mailing Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Delivery Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Last Name, First Name, Middle Name: Neu, Kelvin Mailing Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA Delivery Address: SUITE 540 - 1385 WEST 8TH AVENUE VANCOUVER BC V6H 3V9 CANADA AUTHORIZED SHARE STRUCTURE 1. No Maximum Common Shares Without Par Value With Special Rights or Restrictions attached _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 2. No Maximum Preferred Shares Without Par Value With Special Rights or Restrictions attached _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ Page: 3 of 3