January 4, 2021

Via EDGAR

Securities and Exchange Commission
Division of Corporate Finance
100 F Street, NE
Washington, DC 20549-4561
Attn: Jason Drory

Re:    Daré Bioscience, Inc.
Registration Statement on Form S-1 (File No. 333-251599)

Ladies and Gentlemen:

Pursuant to Rule 461 of the Securities Act of 1933, as amended, Daré Bioscience, Inc. (the "Company") hereby requests that the Securities and Exchange Commission accelerate the effectiveness of the above-referenced registration statement to 4:00 p.m., Eastern Time, on Tuesday, January 5, 2021, or as soon thereafter as practicable.

Daré Bioscience, Inc.

/s/ Lisa Walters-Hoffert

Lisa Walters-Hoffert

Chief Financial Officer