-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 CmoYjuCjEYxJULHvPXv8fw==

<SEC-DOCUMENT>0001401914-10-000003.txt : 20101119
<SEC-HEADER>0001401914-10-000003.hdr.sgml : 20101119
<ACCEPTANCE-DATETIME>20101119150913
ACCESSION NUMBER:		0001401914-10-000003
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20101119
DATE AS OF CHANGE:		20101119
EFFECTIVENESS DATE:		20101119

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cerulean Pharma Inc.
		CENTRAL INDEX KEY:			0001401914
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-150787
		FILM NUMBER:		101205355

	BUSINESS ADDRESS:	
		STREET 1:		161 FIRST STREET
		CITY:			Cambridge
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		617-494-1511

	MAIL ADDRESS:	
		STREET 1:		161 FIRST STREET
		CITY:			Cambridge
		STATE:			MA
		ZIP:			02142

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Tempo Pharmaceuticals Inc
		DATE OF NAME CHANGE:	20070604
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
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<edgarSubmission>

    <schemaVersion>X0704</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001401914</cik>
        <entityName>Cerulean Pharma Inc.</entityName>
        <issuerAddress>
            <street1>840 Memorial Drive</street1>
            <street2>5th Floor</street2>
            <city>Cambridge</city>
            <stateOrCountry>MA</stateOrCountry>
            <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
            <zipCode>02139</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>617-551-9600</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>Tempo Pharmaceuticals Inc</previousName>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2005</value>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alan</firstName>
                <lastName>Crane</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Oliver</firstName>
                <lastName>Fetzer</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Steven</firstName>
                <middleName>E.</middleName>
                <lastName>Hall</lastName>
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                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
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                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>Bryan</firstName>
                <middleName>E.</middleName>
                <lastName>Roberts</lastName>
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                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
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                <firstName>Ram</firstName>
                <lastName>Sasisekharan</lastName>
            </relatedPersonName>
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                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Robert</firstName>
                <lastName>Tepper</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>P.</middleName>
                <lastName>DeMagistris</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alexandra</firstName>
                <lastName>Glucksmann</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
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            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Karen</firstName>
                <lastName>Roberts</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Ryan</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jean</firstName>
                <lastName>Silveri</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>840 Memorial Drive</street1>
                <street2>5th Floor</street2>
                <city>Cambridge</city>
                <stateOrCountry>MA</stateOrCountry>
                <stateOrCountryDescription>MASSACHUSETTS</stateOrCountryDescription>
                <zipCode>02139</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2010-11-12</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>23999989</totalOfferingAmount>
            <totalAmountSold>16499994</totalAmountSold>
            <totalRemaining>7499995</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>17</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Cerulean Pharma Inc.</issuerName>
                <signatureName>/s/ Jean Silveri</signatureName>
                <nameOfSigner>Jean Silveri</nameOfSigner>
                <signatureTitle>Senior Vice President, General Counsel and Secretary</signatureTitle>
                <signatureDate>2010-11-19</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----