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Business and Basis of Presentation - Additional Information (Detail) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Oct. 20, 2016
Oct. 31, 2016
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Net loss     $ (65,781) $ (60,417) $ (203,350) $ (177,565)
Net cash used in operating activities         $ (100,729) (121,437)
Net proceeds from issuance of common stock           $ 205,133
Subsequent Event | Underwritten Public Offering            
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items]            
Net proceeds from issuance of common stock $ 161,800 $ 161,800