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Consolidated Statements of Operations (USD $)
In Thousands, except Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Operating expenses:      
General and administrative $ 19,358us-gaap_GeneralAndAdministrativeExpense $ 9,787us-gaap_GeneralAndAdministrativeExpense $ 24,814us-gaap_GeneralAndAdministrativeExpense
Research and development 122,917us-gaap_ResearchAndDevelopmentExpense 45,046us-gaap_ResearchAndDevelopmentExpense 49,636us-gaap_ResearchAndDevelopmentExpense
Totals 142,275us-gaap_OperatingExpenses 54,833us-gaap_OperatingExpenses 74,450us-gaap_OperatingExpenses
Loss from operations (142,275)us-gaap_OperatingIncomeLoss (54,833)us-gaap_OperatingIncomeLoss (74,450)us-gaap_OperatingIncomeLoss
Other income (expenses):      
Interest income 324us-gaap_InvestmentIncomeInterest 172us-gaap_InvestmentIncomeInterest 98us-gaap_InvestmentIncomeInterest
Other income (expense) (14)us-gaap_OtherNonoperatingIncomeExpense 2us-gaap_OtherNonoperatingIncomeExpense  
Totals 310us-gaap_NonoperatingIncomeExpense 174us-gaap_NonoperatingIncomeExpense 98us-gaap_NonoperatingIncomeExpense
Net loss (141,965)us-gaap_NetIncomeLoss (54,659)us-gaap_NetIncomeLoss (74,352)us-gaap_NetIncomeLoss
Net loss applicable to common stock $ (141,965)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic $ (54,659)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic $ (74,352)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic
Net loss per common share—basic and diluted $ (4.73)us-gaap_EarningsPerShareBasicAndDiluted $ (1.90)us-gaap_EarningsPerShareBasicAndDiluted $ (3.42)us-gaap_EarningsPerShareBasicAndDiluted
Weighted-average common shares outstanding—basic and diluted 30,010,979us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted 28,696,573us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted 21,725,986us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted