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Note 11 - Stockholders' Deficit (Details Textual) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Jul. 15, 2021
Apr. 01, 2021
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Oct. 31, 2011
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period (in shares)     0 18,202 87,625  
Common Stock, Shares Authorized (in shares)     100,000,000 100,000,000    
Common Stock, Par or Stated Value Per Share (in dollars per share)     $ 0.0001 $ 0.0001    
Ordinary Shares Ownership Percentage           20.00%
Share-based Payment Arrangement, Expense     $ 32,633 $ 36,575 $ 57,327  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)     $ 7.90 $ 7.81 $ 12.08  
Equity Incentive Plan Twenty Eleven [Member]            
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized (in shares)   2,000,000        
Common Stock, Capital Shares Reserved for Future Issuance (in shares)     14,545,860      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)     5,068,592      
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)     4,159,934      
Employment Inducement Incentive Award Plan Twenty Seventeen [Member]            
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized (in shares) 1,000,000          
Common Stock, Capital Shares Reserved for Future Issuance (in shares)     3,000,000      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)     925,972      
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)     1,454,340      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)     3 years      
Employment Inducement Incentive Award Plan Twenty Seventeen [Member] | Maximum [Member]            
Share-based Compensation Arrangement By Share-based Payment Award, Options Initial Contractual Term (Year)     10 years      
Selling, General and Administrative Expenses [Member]            
Share-based Payment Arrangement, Expense     $ 13,587 $ 0 $ 0  
Common Stock [Member]            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)     2,116,250      
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)     $ 16      
Restricted Stock Units (RSUs) [Member]            
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period (in shares)     1,089,120 864,881 790,642  
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total     $ 11,000      
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)     1 year 7 months 6 days      
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)     $ 11.44 $ 10.47 $ 14.72  
Restricted Stock Units (RSUs) [Member] | Selling, General and Administrative Expenses [Member]            
Share-based Payment Arrangement, Expense     $ 8,239 $ 13,841 $ 18,848  
Non-vested Stock Options [Member]            
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total     $ 5,100      
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)     1 year 9 months 18 days