schedule13ga.htm

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes)

1	NAMES OF REPORTING PERSON Alta Partners VIII, L.P.

2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP				(a) o
					(b) ý
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER	1,198,195 (a)
		6	SHARED VOTING POWER	-0-
		7	SOLE DISPOSITIVE POWER	1,198,195 (a)
		8	SHARED DISPOSITIVE POWER	-0-
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	1,198,195 (a)
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES *

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	8.7% (b)
12	TYPE OF REPORTING PERSON PN

(a) Alta Partners VIII, L.P. (“AP VIII”) has sole voting and dispositive control over 1,198,195 shares of common stock (“Common Stock”) of Neothetics, Inc. (the “Issuer”), except that Alta Partners Management VIII, LLC (“APM VIII”), the general partner of AP VIII, and Farah Champsi (“Champsi”), Daniel Janney (“Janney”) and Guy Nohra (“Nohra”), managing directors of AP VIII, may be deemed to share dispositive and voting power over such stock. Additional information about AP VIII is set forth in Attachment A hereto.

(b) The percentage set forth in row (11) is based on the 13,730,410 outstanding shares of Common Stock as reported in the Issuer’s 10-Q for the quarter ended September 30, 2015 as filed with the Securities and Exchange Commission on November 12, 2015. The information with respect to the shares of Common Stock beneficially owned by the Reporting Person is provided as of December 31, 2015.

1	NAMES OF REPORTING PERSON
	Alta Partners Management VIII, LLC
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP				(a) o
					(b) ý
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION Delaware
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER	-0-
		6	SHARED VOTING POWER	1,198,195 (c)
		7	SOLE DISPOSITIVE POWER	-0-
		8	SHARED DISPOSITIVE POWER	1,198,195 (c)
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	1,198,195 (c)
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES *

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	8.7% (b)
12	TYPE OF REPORTING PERSON OO
(c)	APM VIII is the general partner of AP VIII and shares voting and dispositive power over the shares of Common Stock held by AP VIII.


1	NAMES OF REPORTING PERSON Farah Champsi

2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP				(a)o
					(b) ý
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION U.S.A.
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER	-0-
		6	SHARED VOTING POWER	1,198,195(e)
		7	SOLE DISPOSITIVE POWER	-0-
		8	SHARED DISPOSITIVE POWER	1,198,195 (e)
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	1,198,195 (e)
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES *

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	8.7% (b)
12	TYPE OF REPORTING PERSON IN
(e)	CChampsi is a managing director of APM VIII and may be deemed to share voting and dispositive control over the 1,198,195 shares of Common Stock held by AP VIII.

1	NAMES OF REPORTING PERSON
	Daniel Janney
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP				(a) o
					(b) ý
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION U.S.A.
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER	-0-
		6	SHARED VOTING POWER	1,198,195 (g)
		7	SOLE DISPOSITIVE POWER	-0-
		8	SHARED DISPOSITIVE POWER	1,198,195 (g)
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	1,198,195 (g)
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES *

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	8.7% (b)
12	TYPE OF REPORTING PERSON IN
(g)	Janney is a managing director of APM VIII and may be deemed to share voting and dispositive control over the 1,198,195 shares of Common Stock held by AP VIII


1	NAMES OF REPORTING PERSON
	Guy Nohra
2	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP				(a) o
					(b) ý
3	SEC USE ONLY
4	CITIZENSHIP OR PLACE OF ORGANIZATION U.S.A.
NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH		5	SOLE VOTING POWER	-0-
		6	SHARED VOTING POWER	1,198,195 (i)
		7	SOLE DISPOSITIVE POWER	-0-
		8	SHARED DISPOSITIVE POWER	1,198,195 (i)
9	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
	1,198,195 (i)
10	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES *

11	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
	8.7% (b)
12	TYPE OF REPORTING PERSON IN

Item 1.
	(a)	Name of Issuer:
		Neothetics, Inc. ("Issuer")

	(b)	Address of Issuer's Principal Executive Offices:
		9171 Towne Center Drive, Suite 270
		San Diego, CA 92122

Item 2.	(a)	Name of Person Filing: Alta Partners VIII, L.P. (“APVIII”) Alta Partners Management VIII, LLC (“APMVIII”) Guy Nohra (“GN”) Daniel Janney (“DJ”) Farah Champsi (“FC”)
	(b)	Address of Principal Business Office: One Embarcadero Center, Suite 3700 San Francisco, CA 94111
	(c)	Citizenship/Place of Organization: Entities: APVIII - Delaware APMVIII - Delaware Individuals: DJ - United States GN - United States FC - United States
	(d)	Title of Class of Securities: Common Stock
	(e)	CUSIP Number: 64066G101

Item 3.	Not Applicable.

Fund Entities	Shares Held Directly	Sole Voting Power	Shared Voting Power	Sole Dispositive Power	Shared Dispositive Power	Beneficial Ownership	Percentage of Class
APVIII	1,198,195	0	1,198,195	0	1,198,195	1,198,195	8.7%
APMVIII	0	0	1,198,195	0	1,198,195	1,198,195	8.7%
DJ	0	0	1,198,195	0	1,198,195	1,198,195	8.7%
GN	0	0	1,198,195	0	1,198,195	1,198,195	8.7%
FC	0	0	1,198,195	0	1,198,195	1,198,195	8.7%

Item 5.	Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following ¨

Item 6.	Ownership of More than Five Percent on Behalf of Another Person
Not applicable.

Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.
Not applicable.

Item 8.	Identification and Classification of Members of the Group
No reporting person is a member of a group as defined in Section 240.13d-1(b)(1)(ii)(J) of the Act.

Item 9.	Notice of Dissolution of Group
Not applicable.
Item 10.	Certification
Not applicable.

Alta Partners VIII, L.P. beneficially owns 1,198,195 shares of Common Stock and exercises sole voting and dispositive control over such shares, except to the extent set forth below.

Alta Partners Management VIII, LLC is the general partner of Alta Partners VIII, L.P. and may be deemed to share the right to direct the voting and dispositive control over the shares held by such fund. Alta Partners Management VIII, LLC disclaims beneficial ownership of all such shares, except to the extent of its pecuniary interest therein.

Mr. Daniel Janney is a managing director of Alta Partners Management VIII, LLC and may be deemed to share the right to direct the voting and dispositive control over the shares held by such fund. Mr. Janney disclaims beneficial ownership of all such shares, except to the extent of his pecuniary interest therein.

Mr. Guy Nohra is a managing director of Alta Partners Management VIII, LLC and may be deemed to share the right to direct the voting and dispositive control over the shares held by such fund. Mr. Nohra disclaims beneficial ownership of all such shares, except to the extent of his pecuniary interest therein.

Ms. Farah Champsi is a managing director of Alta Partners Management VIII, LLC and may be deemed to share the right to direct the voting and dispositive control over the shares held by such fund. Ms. Champsi disclaims beneficial ownership of all such shares, except to the extent of her pecuniary interest therein.

	Rule 13d-1(b)

	Rule 13d-1(c)

X	Rule 13d-1(d)

Date:	February 12, 2016