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Share-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Share-based Compensation Expense
The Company recognized share-based compensation in its Condensed Consolidated Statements of Operations and Comprehensive Loss during 2022 and 2021 as follows:

 Three Months Ended
September 30,		Nine Months Ended
September 30,
 2022202120222021
Manufacture and supply$66 $88 $159 $241 
Research and development75 230 406 670 
Selling, general and administrative394 1,582 3,104 4,217 
Total share-based compensation expenses$535 $1,900 $3,669 $5,128 
Share-based compensation from:
Restricted stock units$58 $— $97 $81 
Stock options477 1,900 3,570 5,036 
Employee stock purchase plan— — 2 11 
Total share-based compensation expenses$535 $1,900 $3,669 $5,128 
Restricted Stock Units Awards
The following tables provide information about the Company’s restricted stock unit and stock option activity during the nine-month period ended September 30, 2022:
Restricted Stock Unit Awards (RSUs):Number of
Units		Weighted
Average
Grant Date Fair
Value
 (in thousands) 
Unvested as of December 31, 2021— $— 
Granted192 $2.38 
Vested(10)$2.55 
Forfeited(14)$2.06 
Unvested as of September 30, 2022168 $2.39 
Vested and expected to vest as of September 30, 2022154 $2.39 
Stock Option Activity
Stock Option Awards:Number of
Options		Weighted Average
Exercise Price
 (in thousands)
Outstanding as of December 31, 20214,146 $7.28 
Granted1,830 $1.93 
Exercised, Forfeited, Expired(9)$10.76 
Outstanding as of September 30, 20225,967 $5.70 
Vested and expected to vest as of September 30, 20225,800 $5.80 
Exercisable as of September 30, 20223,651 $7.62 
Valuation Assumptions for Determination of Fair Value of Options
The fair values of stock options granted during the nine months ended September 30, 2022 were estimated using the Black-Scholes pricing model based on the following assumptions:

Expected dividend yield—%
Expected volatility
100%
Expected term (years)5.5-6.1
Risk-free interest rate2.0 %-3.4%