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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Operating activities:      
Net income (loss) $ 1,856 $ (13,716) $ (63,909)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:      
Depreciation of fixed assets and amortization of intangibles 11,475 10,035 5,747
Amortization of unfavorable lease obligation and debt issuance costs 481 487 459
Amortization of debt discount 4,102 4,139 3,959
Loss on disposal of fixed assets 6 158 32
Loss on early extinguishment of debt 52   3,398
Stock-based compensation 33,368 24,822 11,513
Changes in operating assets and liabilities:      
Restricted cash 1,509 124 (110)
Accounts receivable, net (3,489) (7,776) (10,238)
Inventories (32,382) (13,706) (3,480)
Prepaid expenses and other assets (2,007) (1,621) (972)
Accounts payable and accrued expenses 9,941 15,349 9,622
Royalty interest obligation (276) (970) (434)
Other liabilities 5,786 2,526 1,047
Deferred revenue (1,426) 6,713 (472)
Net cash provided by (used in) operating activities 28,996 26,564 (43,838)
Investing activities:      
Purchases of fixed assets (41,270) (22,984) (12,172)
Purchases of investments (189,082) (164,303) (114,299)
Sales of investments 217,240 80,286 85,564
Payment of contingent consideration (7,119) (13,433) (2,031)
Net cash used in investing activities (20,231) (120,434) (42,938)
Financing activities:      
Proceeds from follow-on public offering, net 0 110,452 0
Proceeds from exercise of stock options and warrants 10,073 7,239 3,856
Proceeds from shares issued under employee stock purchase plan 2,093 1,184 0
Conversion of principal and equity component of convertible senior notes (1,467) 0  
Proceeds from convertible senior notes   0 120,000
Repayment of debt 0   (27,500)
Payment of debt issuance and financing costs 0   (7,191)
Net cash provided by financing activities 10,699 118,875 89,165
Net increase in cash and cash equivalents 19,464 25,005 2,389
Cash and cash equivalents, beginning of year 37,520 12,515 10,126
Cash and cash equivalents, end of year 56,984 37,520 12,515
Supplemental cash flow information:      
Cash paid for interest, including royalty interest obligation 4,224 5,193 3,500
Cash paid for income taxes, net of refunds 195 34 0
Non-cash investing and financing activities:      
Equity component of convertible senior notes 0 0 24,936
Issuance of stock from conversion of convertible senior notes 3,929 0 0
Net increase (decrease) in accrued fixed assets $ 418 $ (1,095) $ 622