CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Operating activities:
Net income	$ 6,227	$ 26,704
Adjustments to reconcile net income to net cash provided by operating activities:
Deferred taxes	4,100	2,193
Depreciation of fixed assets and amortization of intangible assets	38,656	40,897
Amortization of debt issuance costs	1,628	2,053
Amortization of debt discount	703	1,412
Loss on early extinguishment of debt	16,926	0
Loss on disposal of fixed assets	0	193
Stock-based compensation	22,945	22,733
Changes in contingent consideration	(6,640)	(22,351)
Loss on investment	11	108
Changes in operating assets and liabilities:
Accounts receivable, net	(683)	5,213
Inventories, net	3,933	(2,038)
Prepaid expenses and other assets	(4,369)	(3,233)
Accounts payable	9,683	5,258
Accrued expenses and income taxes payable	(30,771)	(19,038)
Other liabilities	278	479
Net cash provided by operating activities	62,627	60,583
Investing activities:
Purchases of fixed assets	(9,969)	(19,403)
Purchases of available-for-sale investments	(69,509)	(187,641)
Sales of available-for-sale investments	159,745	62,936
Payment of contingent consideration	0	(32,000)
Purchases of equity and debt investments	(6,758)	(12,750)
Net cash provided by (used in) investing activities	73,509	(188,858)
Financing activities:
Proceeds from exercises of stock options	1,913	21,881
Proceeds from shares issued under employee stock purchase plan	1,673	1,821
Proceeds from Term loan A facility	149,550	0
Debt extinguishment costs	(5,750)	0
Payment of debt issuance and financing costs	(1,163)	0
Net cash used in financing activities	(153,465)	(335,242)
Net decrease in cash and cash equivalents	(17,329)	(463,517)
Cash and cash equivalents, beginning of period	104,139	585,578
Cash and cash equivalents, end of period	86,810	122,061
Supplemental cash flow information:
Cash paid for interest	20,802	14,686
Cash paid for income taxes, net of refunds	795	4,104
Non-cash investing and financing activities:
Issuance of common stock from conversion of 2022 convertible senior notes	0	3,040
Fixed assets included in accounts payable and accrued liabilities	2,388	2,454
Convertible Senior Notes Due 2022
Financing activities:
Repayment of 2024 convertible senior notes	0	(156,960)
Convertible Senior Notes Due 2024
Financing activities:
Repayment of 2024 convertible senior notes	0	(192,609)
Term Loan B Facility
Financing activities:
Repayment of Term loan B facility	(296,875)	(9,375)
Term Loan A Facility
Financing activities:
Repayment of Term loan B facility	$ (2,813)	$ 0