Issuer Free Writing Prospectus

Filed by Takeda Pharmaceutical Company Limited

Pursuant to Rule 433

Registration Statement No. 333-280469

June 26, 2024

TAKEDA PHARMACEUTICAL COMPANY LIMITED US$1,100,00,000 5.300% SENIOR NOTES DUE 2034

FINAL TERM SHEET

Dated June 27, 2024

Issuer:	Takeda Pharmaceutical Company Limited (the “Company”)
Security:	US$1,100,000,000 5.300% Senior Notes due 2034 (the “Notes”)
Expected Issue Ratings*:	Moody’s: Baa1 (Stable) / S&P: BBB+ (Stable)
Format:	SEC registered
Status of Notes:	Senior, Unsecured
Denomination:	US$200,000 and integral multiples of US$1,000 in excess thereof
Pricing Date:	June 27, 2024
Settlement Date:	July 5, 2024 (T+5)
Maturity Date:	July 5, 2034
Principal Amount:	US$1,100,000,000
Coupon:	5.300% (per annum, payable semi-annually in arrears)
Interest Payment Dates:	January 5 and July 5 of each year, commencing January 5, 2025
Issue Price:	99.724% plus accrued interest, if any, if settlement occurs after July 5, 2024
Benchmark Treasury:	4.375% due May 15, 2034
Benchmark Treasury Price/Yield:	100-22+ / 4.286%
Spread to Benchmark:	T+105 bps
Yield to Maturity:	5.336%
Day Count Fraction:	30/360, unadjusted
Business Days:	New York, London, Tokyo
Business Day Convention:	Following
Joint Bookrunners:	J.P. Morgan Securities LLC Morgan Stanley & Co. LLC BofA Securities, Inc.

Passive Bookrunners:	BNP Paribas HSBC Securities (USA) Inc. Wells Fargo Securities, LLC Barclays Capital Inc.
Co-Managers[**]:	SMBC Nikko Securities America, Inc. Mizuho Securities USA LLC Nomura Securities International, Inc. Citigroup Global Markets Inc. Goldman Sachs & Co. LLC Commerz Markets LLC ING FINANCIAL MARKETS LLC
Billing & Delivery:	BofA Securities, Inc.
Trustee:	The Bank of New York Mellon
Settlement:	DTC, Euroclear and Clearstream
Optional Redemption:	The Company has the option to redeem the Notes, in whole or in part, at any time prior to April 5, 2034 (the “Par Call Date”), at a redemption price equal to the greater of (i) (a) the sum of the present values of the remaining scheduled payments of principal and interest thereon discounted to the redemption date (assuming the notes being redeemed matured on the Par Call Date) on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined in the preliminary prospectus supplement dated June 27, 2024 relating to the Notes (the “Preliminary Prospectus Supplement”)) plus 20 basis points less (b) interest accrued to the date of redemption, and (ii) 100% of the principal amount of the Notes being redeemed; plus, in each case, accrued and unpaid interest thereon to, but excluding, the redemption date. On or after the Par Call Date, the Company may redeem the Notes, in whole or in part, at any time and from time to time, at a redemption price equal to 100% of the principal amount of the Notes being redeemed plus accrued and unpaid interest thereon to, but excluding, the redemption date.
Optional Tax Redemption:	The Notes may be redeemed at any time, at the Company’s option and sole discretion, in whole, but not in part, and upon giving not less than 30 nor more than 60 days’ notice of redemption to the trustee and the holders (which notice shall be irrevocable), at the principal amount of the Notes together with interest accrued to the date fixed for redemption and any additional amounts thereon, if the Company has been or will be obliged to pay any additional amounts with respect to such Notes as a result of (a) any change in, or amendment to, the laws or regulations of Japan or any political subdivision or any authority thereof or therein having power to tax, or any change in application or official interpretation of such laws or regulations, which change or amendment becomes effective on or after the date of the issuance of the Notes or (b) after the completion of any Succession Event (as defined in the Preliminary Prospectus Supplement), any change in, or amendment to, the laws or regulations of the jurisdiction of the succeeding entity or any political subdivision or any authority thereof or therein having power to tax, or any change in application or official interpretation of such laws or regulations, which change or amendment becomes effective on or after the date of such Succession Event, and in either case such obligation cannot be avoided through the taking of reasonable measures available to us or the succeeding entity, as the case may be.

Use of Proceeds:	We intend to use a portion of the net proceeds from the offering of the Notes to settle the Tender Offers, with the remainder of the proceeds of the offering of the Notes to be used to repay outstanding borrowings under our commercial paper facility.
CUSIP:	874060BK1
ISIN:	US874060BK18
Common Code:	282964767
Governing Law:	New York Law

* A security rating is not a recommendation to buy, sell or hold securities and may be subject to suspension, reduction or withdrawal at any time by the assigning rating agencies.

** One or more of the underwriters may not be U.S.-registered broker-dealers. All sales of securities in the United States will be made by or through U.S.-registered broker-dealers, which may include affiliates of one or more of the underwriters.

The Company has filed a registration statement (including a prospectus dated June 26, 2024 (the “Base Prospectus”)) and a preliminary prospectus supplement dated June 27, 2024 (together with the Base Prospectus, the “Preliminary Prospectus”) with the U.S. Securities and Exchange Commission (the “SEC”) for the offering to which this communication relates. Before you invest, you should read the Preliminary Prospectus and other documents the Company has filed with the SEC for more complete information about the Company and this offering. You may obtain these documents for free by visiting EDGAR on the SEC Web site at www.sec.gov. Alternatively, the Company, any underwriter or any dealer participating in the offering will arrange to send you the prospectus, if you request it by calling J.P. Morgan Securities LLC (collect) at (212) 834-4533, Morgan Stanley & Co. LLC toll-free at 1-866-718-1649 or BofA Securities, Inc. at 1-800-294-1322.

This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction.

No PRIIPs KID - No PRIIPs key information document (KID) has been prepared as the Notes are not available to retail investors in the EEA or in the United Kingdom. See “PROHIBITION OF SALES TO EEA RETAIL INVESTORS AND PROHIBITION OF SALES TO U.K. RETAIL INVESTORS” in the

Preliminary Prospectus.

TAKEDA PHARMACEUTICAL COMPANY LIMITED

US$800,000,000 5.650% SENIOR NOTES DUE 2044

FINAL TERM SHEET

Dated June 27, 2024

Issuer:	Takeda Pharmaceutical Company Limited (the “Company”)
Security:	US$800,000,000 5.650% Senior Notes due 2044 (the “Notes”)
Expected Issue Ratings*:	Moody’s: Baa1 (Stable) / S&P: BBB+ (Stable)
Format:	SEC registered
Status of Notes:	Senior, Unsecured
Denomination:	US$200,000 and integral multiples of US$1,000 in excess thereof
Pricing Date:	June 27, 2024
Settlement Date:	July 5, 2024 (T+5)
Maturity Date:	July 5, 2044
Principal Amount:	US$800,000,000
Coupon:	5.650% (per annum, payable semi-annually in arrears)
Interest Payment Dates:	January 5 and July 5 of each year, commencing January 5, 2025
Issue Price:	99.561% plus accrued interest, if any, if settlement occurs after July 5, 2024
Benchmark Treasury:	4.625% due May 15, 2044
Benchmark Treasury Price/Yield:	101-04+ / 4.537%
Spread to Benchmark:	T+115 bps
Yield to Maturity:	5.687%
Day Count Fraction:	30/360, unadjusted
Business Days:	New York, London, Tokyo
Business Day Convention:	Following
Joint Bookrunners:	J.P. Morgan Securities LLC Morgan Stanley & Co. LLC BofA Securities, Inc.

Passive Bookrunners:	BNP Paribas HSBC Securities (USA) Inc. Wells Fargo Securities, LLC Barclays Capital Inc.
Co-Managers[**]:	SMBC Nikko Securities America, Inc. Mizuho Securities USA LLC Nomura Securities International, Inc. Citigroup Global Markets Inc. Goldman Sachs & Co. LLC Commerz Markets LLC ING FINANCIAL MARKETS LLC
Billing & Delivery:	BofA Securities, Inc.
Trustee:	The Bank of New York Mellon
Settlement:	DTC, Euroclear and Clearstream
Optional Redemption:	The Company has the option to redeem the Notes, in whole or in part, at any time prior to January 5, 2044 (the “Par Call Date”), at a redemption price equal to the greater of (i) (a) the sum of the present values of the remaining scheduled payments of principal and interest thereon discounted to the redemption date (assuming the notes being redeemed matured on the Par Call Date) on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined in the preliminary prospectus supplement dated June 27, 2024 relating to the Notes (the “Preliminary Prospectus Supplement”)) plus 20 basis points less (b) interest accrued to the date of redemption, and (ii) 100% of the principal amount of the Notes being redeemed; plus, in each case, accrued and unpaid interest thereon to, but excluding, the redemption date. On or after the Par Call Date, the Company may redeem the Notes, in whole or in part, at any time and from time to time, at a redemption price equal to 100% of the principal amount of the Notes being redeemed plus accrued and unpaid interest thereon to, but excluding, the redemption date.
Optional Tax Redemption:	The Notes may be redeemed at any time, at the Company’s option and sole discretion, in whole, but not in part, and upon giving not less than 30 nor more than 60 days’ notice of redemption to the trustee and the holders (which notice shall be irrevocable), at the principal amount of the Notes together with interest accrued to the date fixed for redemption and any additional amounts thereon, if the Company has been or will be obliged to pay any additional amounts with respect to such Notes as a result of (a) any change in, or amendment to, the laws or regulations of Japan or any political subdivision or any authority thereof or therein having power to tax, or any change in application or official interpretation of such laws or regulations, which change or amendment becomes effective on or after the date of the issuance of the Notes or (b) after the completion of any Succession Event (as defined in the Preliminary Prospectus Supplement), any change in, or amendment to, the laws or regulations of the jurisdiction of the succeeding entity or any political subdivision or any authority thereof or therein having power to tax, or any change in application or official interpretation of such laws or regulations, which change or amendment becomes effective on or after the date of such Succession Event, and in either case such obligation cannot be avoided through the taking of reasonable measures available to us or the succeeding entity, as the case may be.

Use of Proceeds:	We intend to use a portion of the net proceeds from the offering of the Notes to settle the Tender Offers, with the remainder of the proceeds of the offering of the Notes to be used to repay outstanding borrowings under our commercial paper facility.
CUSIP:	874060BL9
ISIN:	US874060BL90
Common Code:	282964457
Governing Law:	New York Law

* A security rating is not a recommendation to buy, sell or hold securities and may be subject to suspension, reduction or withdrawal at any time by the assigning rating agencies.

** One or more of the underwriters may not be U.S.-registered broker-dealers. All sales of securities in the United States will be made by or through U.S.-registered broker-dealers, which may include affiliates of one or more of the underwriters.

The Company has filed a registration statement (including a prospectus dated June 26, 2024 (the “Base Prospectus”)) and a preliminary prospectus supplement dated June 27, 2024 (together with the Base Prospectus, the “Preliminary Prospectus”) with the U.S. Securities and Exchange Commission (the “SEC”) for the offering to which this communication relates. Before you invest, you should read the Preliminary Prospectus and other documents the Company has filed with the SEC for more complete information about the Company and this offering. You may obtain these documents for free by visiting EDGAR on the SEC Web site at www.sec.gov. Alternatively, the Company, any underwriter or any dealer participating in the offering will arrange to send you the prospectus, if you request it by calling J.P. Morgan Securities LLC (collect) at (212) 834-4533, Morgan Stanley & Co. LLC toll-free at 1-866-718-1649 or BofA Securities, Inc. at 1-800-294-1322.

This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction.

No PRIIPs KID - No PRIIPs key information document (KID) has been prepared as the Notes are not available to retail investors in the EEA or in the United Kingdom. See “PROHIBITION OF SALES TO EEA RETAIL INVESTORS AND PROHIBITION OF SALES TO U.K. RETAIL INVESTORS” in the

Preliminary Prospectus.

TAKEDA PHARMACEUTICAL COMPANY LIMITED

US$600,000,000 5.650% SENIOR NOTES DUE 2054

FINAL TERM SHEET

Dated June 27, 2024

Issuer:	Takeda Pharmaceutical Company Limited (the “Company”)
Security:	US$600,000,000 5.650% Senior Notes due 2054 (the “Notes”)
Expected Issue Ratings*:	Moody’s: Baa1 (Stable)] / S&P: BBB+ (Stable)
Format:	SEC registered
Status of Notes:	Senior, Unsecured
Denomination:	US$200,000 and integral multiples of US$1,000 in excess thereof
Pricing Date:	June 27, 2024
Settlement Date:	July 5, 2024 (T+5)
Maturity Date:	July 5, 2054
Principal Amount:	US$600,000,000
Coupon:	5.650% (per annum, payable semi-annually in arrears)
Interest Payment Dates:	January 5 and July 5 of each year, commencing January 5, 2025
Issue Price:	99.570% plus accrued interest, if any, if settlement occurs after July 5, 2024
Benchmark Treasury:	4.250% due February 15, 2054
Benchmark Treasury Price/Yield:	97-01+ / 4.430%
Spread to Benchmark:	T+125 bps
Yield to Maturity:	5.680%
Day Count Fraction:	30/360, unadjusted
Business Days:	New York, London, Tokyo
Business Day Convention:	Following
Joint Bookrunners:	J.P. Morgan Securities LLC Morgan Stanley & Co. LLC BofA Securities, Inc.

Passive Bookrunners:	BNP Paribas HSBC Securities (USA) Inc. Wells Fargo Securities, LLC Barclays Capital Inc.
Co-Managers[**]:	SMBC Nikko Securities America, Inc. Mizuho Securities USA LLC Nomura Securities International, Inc. Citigroup Global Markets Inc. Goldman Sachs & Co. LLC Commerz Markets LLC ING FINANCIAL MARKETS LLC
Billing & Delivery:	BofA Securities, Inc.
Trustee:	The Bank of New York Mellon
Settlement:	DTC, Euroclear and Clearstream
Optional Redemption:	The Company has the option to redeem the Notes, in whole or in part, at any time prior to January 5, 2054 (the “Par Call Date”), at a redemption price equal to the greater of (i) (a) the sum of the present values of the remaining scheduled payments of principal and interest thereon discounted to the redemption date (assuming the notes being redeemed matured on the Par Call Date) on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined in the preliminary prospectus supplement dated June 27, 2024 relating to the Notes (the “Preliminary Prospectus Supplement”)) plus 20 basis points less (b) interest accrued to the date of redemption, and (ii) 100% of the principal amount of the Notes being redeemed; plus, in each case, accrued and unpaid interest thereon to, but excluding, the redemption date. On or after the Par Call Date, the Company may redeem the Notes, in whole or in part, at any time and from time to time, at a redemption price equal to 100% of the principal amount of the Notes being redeemed plus accrued and unpaid interest thereon to, but excluding, the redemption date.
Optional Tax Redemption:	The Notes may be redeemed at any time, at the Company’s option and sole discretion, in whole, but not in part, and upon giving not less than 30 nor more than 60 days’ notice of redemption to the trustee and the holders (which notice shall be irrevocable), at the principal amount of the Notes together with interest accrued to the date fixed for redemption and any additional amounts thereon, if the Company has been or will be obliged to pay any additional amounts with respect to such Notes as a result of (a) any change in, or amendment to, the laws or regulations of Japan or any political subdivision or any authority thereof or therein having power to tax, or any change in application or official interpretation of such laws or regulations, which change or amendment becomes effective on or after the date of the issuance of the Notes or (b) after the completion of any Succession Event (as defined in the Preliminary Prospectus Supplement), any change in, or amendment to, the laws or regulations of the jurisdiction of the succeeding entity or any political subdivision or any authority thereof or therein having power to tax, or any change in application or official interpretation of such laws or regulations, which change or amendment becomes effective on or after the date of such Succession Event, and in either case such obligation cannot be avoided through the taking of reasonable measures available to us or the succeeding entity, as the case may be.

Use of Proceeds:	We intend to use a portion of the net proceeds from the offering of the Notes to settle the Tender Offers, with the remainder of the proceeds of the offering of the Notes to be used to repay outstanding borrowings under our commercial paper facility.
CUSIP:	874060BM7
ISIN:	US874060BM73
Common Code:	282964422
Governing Law:	New York Law

* A security rating is not a recommendation to buy, sell or hold securities and may be subject to suspension, reduction or withdrawal at any time by the assigning rating agencies.

** One or more of the underwriters may not be U.S.-registered broker-dealers. All sales of securities in the United States will be made by or through U.S.-registered broker-dealers, which may include affiliates of one or more of the underwriters.

The Company has filed a registration statement (including a prospectus dated June 26, 2024 (the “Base Prospectus”)) and a preliminary prospectus supplement dated June 27, 2024 (together with the Base Prospectus, the “Preliminary Prospectus”) with the U.S. Securities and Exchange Commission (the “SEC”) for the offering to which this communication relates. Before you invest, you should read the Preliminary Prospectus and other documents the Company has filed with the SEC for more complete information about the Company and this offering. You may obtain these documents for free by visiting EDGAR on the SEC Web site at www.sec.gov. Alternatively, the Company, any underwriter or any dealer participating in the offering will arrange to send you the prospectus, if you request it by calling J.P. Morgan Securities LLC (collect) at (212) 834-4533, Morgan Stanley & Co. LLC toll-free at 1-866-718-1649 or BofA Securities, Inc. at 1-800-294-1322.

This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction.

No PRIIPs KID - No PRIIPs key information document (KID) has been prepared as the Notes are not available to retail investors in the EEA or in the United Kingdom. See “PROHIBITION OF SALES TO EEA RETAIL INVESTORS AND PROHIBITION OF SALES TO U.K. RETAIL INVESTORS” in the

Preliminary Prospectus.

TAKEDA PHARMACEUTICAL COMPANY LIMITED

US$500,000,000 5.800% SENIOR NOTES DUE 2064

FINAL TERM SHEET

Dated June 27, 2024

Issuer:	Takeda Pharmaceutical Company Limited (the “Company”)
Security:	US$500,000,000 5.800% Senior Notes due 2064 (the “Notes”)
Expected Issue Ratings*:	Moody’s: Baa1 (Stable) / S&P: BBB+ (Stable)
Format:	SEC registered
Status of Notes:	Senior, Unsecured
Denomination:	US$200,000 and integral multiples of US$1,000 in excess thereof
Pricing Date:	June 27, 2024
Settlement Date:	July 5, 2024 (T+5)
Maturity Date:	July 5, 2064
Principal Amount:	US$500,000,000
Coupon:	5.800% (per annum, payable semi-annually in arrears)
Interest Payment Dates:	January 5 and July 5 of each year, commencing January 5, 2025
Issue Price:	99.537% plus accrued interest, if any, if settlement occurs after July 5, 2024
Benchmark Treasury:	4.250% due February 15, 2054
Benchmark Treasury Price/Yield:	97-01+ / 4.430%
Spread to Benchmark:	T+140 bps
Yield to Maturity:	5.830%
Day Count Fraction:	30/360, unadjusted
Business Days:	New York, London, Tokyo
Business Day Convention:	Following
Joint Bookrunners:	J.P. Morgan Securities LLC Morgan Stanley & Co. LLC BofA Securities, Inc.

Passive Bookrunners:	BNP Paribas HSBC Securities (USA) Inc. Wells Fargo Securities, LLC Barclays Capital Inc.
Co-Managers[**]:	SMBC Nikko Securities America, Inc. Mizuho Securities USA LLC Nomura Securities International, Inc. Citigroup Global Markets Inc. Goldman Sachs & Co. LLC Commerz Markets LLC ING FINANCIAL MARKETS LLC
Billing & Delivery:	BofA Securities, Inc.
Trustee:	The Bank of New York Mellon
Settlement:	DTC, Euroclear and Clearstream
Optional Redemption:	The Company has the option to redeem the Notes, in whole or in part, at any time prior to January 5, 2064 (the “Par Call Date”), at a redemption price equal to the greater of (i) (a) the sum of the present values of the remaining scheduled payments of principal and interest thereon discounted to the redemption date (assuming the notes being redeemed matured on the Par Call Date) on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined in the preliminary prospectus supplement dated June 27, 2024 relating to the Notes (the “Preliminary Prospectus Supplement”)) plus 25 basis points less (b) interest accrued to the date of redemption, and (ii) 100% of the principal amount of the Notes being redeemed; plus, in each case, accrued and unpaid interest thereon to, but excluding, the redemption date. On or after the Par Call Date, the Company may redeem the Notes, in whole or in part, at any time and from time to time, at a redemption price equal to 100% of the principal amount of the Notes being redeemed plus accrued and unpaid interest thereon to, but excluding, the redemption date.
Optional Tax Redemption:	The Notes may be redeemed at any time, at the Company’s option and sole discretion, in whole, but not in part, and upon giving not less than 30 nor more than 60 days’ notice of redemption to the trustee and the holders (which notice shall be irrevocable), at the principal amount of the Notes together with interest accrued to the date fixed for redemption and any additional amounts thereon, if the Company has been or will be obliged to pay any additional amounts with respect to such Notes as a result of (a) any change in, or amendment to, the laws or regulations of Japan or any political subdivision or any authority thereof or therein having power to tax, or any change in application or official interpretation of such laws or regulations, which change or amendment becomes effective on or after the date of the issuance of the Notes or (b) after the completion of any Succession Event (as defined in the Preliminary Prospectus Supplement), any change in, or amendment to, the laws or regulations of the jurisdiction of the succeeding entity or any political subdivision or any authority thereof or therein having power to tax, or any change in application or official interpretation of such laws or regulations, which change or amendment becomes effective on or after the date of such Succession Event, and in either case such obligation cannot be avoided through the taking of reasonable measures available to us or the succeeding entity, as the case may be.

Use of Proceeds:	We intend to use a portion of the net proceeds from the offering of the Notes to settle the Tender Offers, with the remainder of the proceeds of the offering of the Notes to be used to repay outstanding borrowings under our commercial paper facility.
CUSIP:	874060BN5
ISIN:	US874060BN56
Common Code:	282964724
Governing Law:	New York Law

* A security rating is not a recommendation to buy, sell or hold securities and may be subject to suspension, reduction or withdrawal at any time by the assigning rating agencies.

** One or more of the underwriters may not be U.S.-registered broker-dealers. All sales of securities in the United States will be made by or through U.S.-registered broker-dealers, which may include affiliates of one or more of the underwriters.

The Company has filed a registration statement (including a prospectus dated June 26, 2024 (the “Base Prospectus”)) and a preliminary prospectus supplement dated June 27, 2024 (together with the Base Prospectus, the “Preliminary Prospectus”) with the U.S. Securities and Exchange Commission (the “SEC”) for the offering to which this communication relates. Before you invest, you should read the Preliminary Prospectus and other documents the Company has filed with the SEC for more complete information about the Company and this offering. You may obtain these documents for free by visiting EDGAR on the SEC Web site at www.sec.gov. Alternatively, the Company, any underwriter or any dealer participating in the offering will arrange to send you the prospectus, if you request it by calling J.P. Morgan Securities LLC (collect) at (212) 834-4533, Morgan Stanley & Co. LLC toll-free at 1-866-718-1649 or BofA Securities, Inc. at 1-800-294-1322.

This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities in any jurisdiction to any person to whom it is unlawful to make such offer or solicitation in such jurisdiction.

No PRIIPs KID - No PRIIPs key information document (KID) has been prepared as the Notes are not available to retail investors in the EEA or in the United Kingdom. See “PROHIBITION OF SALES TO EEA RETAIL INVESTORS AND PROHIBITION OF SALES TO U.K. RETAIL INVESTORS” in the

Preliminary Prospectus.

Any disclaimer or other notice that may appear below is not applicable to this communication and should be disregarded. Such disclaimer or notice was automatically generated as a result of this communication being sent by Bloomberg or another email system.