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Note 11 - Stock-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2019
Notes Tables  
Share-based Payment Arrangement, Cost by Plan [Table Text Block]
   
Three Months Ended
September
 
30
,
   
Nine
Months Ended
September
 
30
,
 
   
2019
   
2018
   
2019
   
2018
 
Stock options and employee stock purchase plan awards
                               
Research and development
  $
    $
3
    $
    $
21
 
Selling, general and administrative
   
 —
     
7
     
     
48
 
                                 
Restricted stock
                               
Research and development
   
68
     
23
     
129
     
57
 
Selling, general and administrative
   
236
     
136
     
581
     
194
 
                                 
Stock appreciation rights
                               
Research and development
   
132
     
     
114
     
 
Selling, general and administrative
   
132
     
112
     
114
     
198
 
Total stock-based compensation
  $
568
    $
281
    $
938
    $
518
 
Share-based Payment Arrangement, Option, Activity [Table Text Block]
   
Number of Options
 
Options outstanding at December 31, 2018
   
2,313
 
Granted
   
 
Canceled or forfeited
   
(749
)
Exercised
   
 
Options outstanding at September 30, 2019
   
1,564
 
Weighted-average remaining contractual life (in years)
   
5.7
 
Schedule of Nonvested Share Activity [Table Text Block]
   
Shares
   
Weighted -Average Grant
Date Fair Value
 
Unvested RSAs at December 31, 2018
   
290,300
    $
3.45
 
Granted
   
1,308,613
    $
1.91
 
Vested
   
(254,500
)   $
3.45
 
Canceled or forfeited
   
(35,800
)   $
3.45
 
Unvested RSAs at September 30, 2019
   
1,308,613
    $
1.91