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Note 10 - Stock-Based Compensation
3 Months Ended
Mar. 31, 2019
Notes to Financial Statements  
Share-based Payment Arrangement [Text Block]
10.
Stock-Based Compensation
 
The Company records stock-based compensation expense during the requisite service period for share-based payment awards granted to employees and non-employees.
 
The following table sets forth the Company’s stock-based compensation expense (in thousands) for the periods indicated.
 
   
Three Months Ended March 31,
 
   
2019
   
2018
 
Stock options and employee stock purchase plan awards
               
Research and development
  $
    $
10
 
Selling, general and administrative
   
     
30
 
                 
Restricted stock
               
Research and development
   
28
     
17
 
Selling, general and administrative    
206
     
41
 
                 
Stock appreciation rights                
Research and development    
16
     
 
Selling, general and administrative
   
13
     
 
Total stock-based compensation
  $
263
    $
98