-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0001392253-09-000003.txt : 20090505
<SEC-HEADER>0001392253-09-000003.hdr.sgml : 20090505
<ACCEPTANCE-DATETIME>20090505135259
ACCESSION NUMBER:		0001392253-09-000003
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090505
DATE AS OF CHANGE:		20090505
EFFECTIVENESS DATE:		20090505

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ENTEGRION INC
		CENTRAL INDEX KEY:			0001392253
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-100842
		FILM NUMBER:		09796756

	BUSINESS ADDRESS:	
		STREET 1:		79 TW ALEXANDER DR
		STREET 2:		4401 RESEARCH COMMON SUI 200
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709
		BUSINESS PHONE:		919-536-1500

	MAIL ADDRESS:	
		STREET 1:		79 TW ALEXANDER DR
		STREET 2:		4401 RESEARCH COMMON SUI 200
		CITY:			RESEARCH TRIANGLE PARK
		STATE:			NC
		ZIP:			27709
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001392253</cik>
        <entityName>ENTEGRION INC</entityName>
        <issuerAddress>
            <street1>79 TW ALEXANDER DR</street1>
            <street2>4401 RESEARCH COMMON SUI 200</street2>
            <city>RESEARCH TRIANGLE PARK</city>
            <stateOrCountry>NC</stateOrCountry>
            <zipCode>27709</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>919-536-1500</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>Hemocellular Therapeutics, Inc.</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>E.</firstName>
                <middleName>S.</middleName>
                <lastName>Eskridge, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Richard</firstName>
                <middleName></middleName>
                <lastName>Martin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>William</firstName>
                <middleName>S.</middleName>
                <lastName>Corbitt, III</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Norman</firstName>
                <middleName>E.</middleName>
                <lastName>Thagard</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stephen</firstName>
                <middleName>R.</middleName>
                <lastName>Petteway, Jr.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Patrick</firstName>
                <middleName>F.</middleName>
                <lastName>Nash</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>L.</middleName>
                <lastName>Edwards</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>B.</middleName>
                <lastName>Mowell</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>James</firstName>
                <middleName>T.</middleName>
                <lastName>Martin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>R.</firstName>
                <middleName>Les</middleName>
                <lastName>Brownlee</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>79 TW Alexander Drive</street1>
                <street2>4401 Research Commons, Suite 200</street2>
                <city>Research Triangle Park</city>
                <stateOrCountry>NC</stateOrCountry>
                <zipCode>27709</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-04-24</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isDebtType>true</isDebtType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>1000000</totalOfferingAmount>
            <totalAmountSold>10000</totalAmountSold>
            <totalRemaining>990000</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>Other than the payment of salaries and other compensation and benefits no officer, director or promoter will receive any payments from the proceeds of this offering.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>ENTEGRION INC</issuerName>
                <signatureName>/s/ Richard Martin</signatureName>
                <nameOfSigner>Richard Martin</nameOfSigner>
                <signatureTitle>CFO</signatureTitle>
                <signatureDate>2009-05-05</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----