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Note 14 - License, Collaboration and Distribution Agreements (Tables)
6 Months Ended
Jun. 30, 2019
Notes Tables  
Contract with Customer, Asset and Liability [Table Text Block]
   
Balance at Beginning of the Period
   
Additions
   
Deductions
   
Balance at the end of the
Period
 
   
(in thousands)
 
Contract Liabilities: Deferred Revenue
  $
41
    $
-
    $
(41
)   $
-
 
Contract Liabilities: Accrued Liabilities
   
1,432
     
4,001
     
(5,119
)    
314
 
Total
  $
1,473
    $
4,001
    $
(5,160
)   $
314
 
Disaggregation of Revenue [Table Text Block]
   
Six Months Ended June 30,
 
   
2019
   
2018
 
Revenue recognized in the period from:
               
Amounts included in contract liabilities at the beginning of the period:
               
Performance obligations satisfied
  $
1,473
    $
1,426
 
New activities in the period:
               
Performance obligations satisfied
   
1,807
     
4,315
 
                 
    $
3,280
    $
5,741