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Commitments and Contingencies - Narrative (Details)
$ in Thousands
1 Months Ended 3 Months Ended
Mar. 18, 2021
ft²
optionToExtend
Sep. 03, 2019
USD ($)
Oct. 04, 2018
ft²
optionToExtend
Dec. 31, 2021
ft²
optionToExtend
Mar. 31, 2022
USD ($)
Mar. 31, 2021
USD ($)
May 06, 2022
USD ($)
Feb. 15, 2022
Feb. 14, 2022
ft²
Dec. 31, 2019
USD ($)
Oct. 29, 2009
ft²
Lessee, Lease, Description [Line Items]                      
Operating lease, cost         $ 3,400            
Operating lease, payments         3,200            
Sublease percentage               50.00%      
Impairment charges         $ 23,164 $ 0          
Weighted average remaining term of operating leases (in years)         9 years 6 months 21 days            
Weighted average discount rate of operating leases (as a percent)         728.00%            
Collaboration agreement milestone payments         $ 0            
Collaboration agreement, additional milestone payments, between 2022 and early 2023         1,750            
ROU Asset                      
Lessee, Lease, Description [Line Items]                      
Impairment charges         $ 20,451            
Subsequent Event                      
Lessee, Lease, Description [Line Items]                      
Collaboration agreement milestone payments             $ 11,000        
Verily Life Sciences LLC                      
Lessee, Lease, Description [Line Items]                      
Remaining term of agreement   24 months                  
Upfront fee related to development agreement                   $ 5,000  
Additional aggregate milestone payments related to development agreement   $ 12,750                  
Lincolnshire Lease                      
Lessee, Lease, Description [Line Items]                      
Lease rentable area | ft²                     41,500
Cypress Lease                      
Lessee, Lease, Description [Line Items]                      
Lease rentable area | ft² 68,933                    
Renewal term of lease (in years) 5 years                    
Deerfield Lease                      
Lessee, Lease, Description [Line Items]                      
Renewal term of lease (in years)       5 years              
Encinitas Lease                      
Lessee, Lease, Description [Line Items]                      
Lease rentable area | ft²                 3,238    
San Francisco | Office Lease                      
Lessee, Lease, Description [Line Items]                      
Lease rentable area | ft²     117,560                
Number of option to extend | optionToExtend     1 1              
Renewal term of lease (in years)     5 years                
San Francisco | Cypress Lease                      
Lessee, Lease, Description [Line Items]                      
Number of option to extend | optionToExtend 1                    
San Francisco | Deerfield Lease                      
Lessee, Lease, Description [Line Items]                      
Lease rentable area | ft²       44,616