The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   29,386,000 1,400,000 SH   SOLE   1,400,000 0 0
ABCELLERA BIOLOGICS INC COM 00288U106   3,335,668 1,126,915 SH   SOLE   1,126,915 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   36,059,544 500,827 SH   SOLE   500,827 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   28,767,069 118,383 SH   SOLE   118,383 0 0
AMICUS THERAPEUTICS INC COM 03152W109   24,800,000 2,500,000 SH   SOLE   2,500,000 0 0
APPLE INC COM 037833100   38,535,035 182,960 SH   SOLE   182,960 0 0
ARRIVENT BIOPHARMA INC COM 04272N102   27,825,000 1,500,000 SH   SOLE   1,500,000 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210   136,366,727 133,336 SH   SOLE   133,336 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   40,341,700 490,000 SH   SOLE   490,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   18,861,500 175,000 SH   SOLE   175,000 0 0
BROOKFIELD ASSET MANAGMT LTD CL A LMT VTG SHS 113004105   23,865,226 627,207 SH   SOLE   627,207 0 0
BROOKFIELD CORP CL A LTD VT SH 11271J107   161,184,754 3,880,230 SH   SOLE   3,880,230 0 0
CABLE ONE INC COM 12685J105   41,914,662 118,403 SH   SOLE   118,403 0 0
CARGO THERAPEUTICS INC COM 14179K101   25,352,480 1,544,000 SH   SOLE   1,544,000 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   31,458,500 850,000 SH   SOLE   850,000 0 0
CORCEPT THERAPEUTICS INC COM 218352102   78,345,151 2,411,362 SH   SOLE   2,411,362 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   44,790,000 1,000,000 SH   SOLE   1,000,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   114,263,184 6,344,430 SH   SOLE   6,344,430 0 0
GALECTO INC COM 36322Q107   1,183,953 2,497,791 SH   SOLE   2,497,791 0 0
INSMED INC COM PAR $.01 457669307   53,600,000 800,000 SH   SOLE   800,000 0 0
IO BIOTECH INC COM 449778109   5,182,455 4,429,449 SH   SOLE   4,429,449 0 0
KYVERNA THERAPEUTICS INC COM 501976104   13,125,000 1,750,000 SH   SOLE   1,750,000 0 0
LANZATECH GLOBAL INC COM 51655R101   29,257,463 15,814,845 SH   SOLE   15,814,845 0 0
LEXEO THERAPEUTICS INC COM 52886X107   23,266,020 1,450,500 SH   SOLE   1,450,500 0 0
MARQETA INC CLASS A COM 57142B104   2,419,738 441,558 SH   SOLE   441,558 0 0
MERUS N V COM N5749R100   39,939,750 675,000 SH   SOLE   675,000 0 0
METAGENOMI INC COM 59102M104   7,344,000 1,800,000 SH   SOLE   1,800,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   51,285,000 1,500,000 SH   SOLE   1,500,000 0 0
MORPHIC HLDG INC COM 61775R105   12,776,250 375,000 SH   SOLE   375,000 0 0
PHARVARIS N V COM N69605108   32,430,000 1,725,000 SH   SOLE   1,725,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   23,683,000 1,100,000 SH   SOLE   1,100,000 0 0
SALESFORCE INC COM 79466L302   123,449,136 480,160 SH   SOLE   480,160 0 0
SPERO THERAPEUTICS INC COM 84833T103   609,573 468,902 SH   SOLE   468,902 0 0
TEMPUS AI INC CL A 88023B103   142,604,665 4,074,419 SH   SOLE   4,074,419 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769   277,822,510 1,038,550 SH   SOLE   1,038,550 0 0
VAXCYTE INC COM 92243G108   71,734,500 950,000 SH   SOLE   950,000 0 0
VERVE THERAPEUTICS INC COM 92539P101   11,712,000 2,400,000 SH   SOLE   2,400,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   26,020,000 2,000,000 SH   SOLE   2,000,000 0 0