STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE ANNUAL MEETING AND VOTE IN PERSON.

To the Stockholders of ACTINIUM PHARMACEUTICALS, INC.

Notice is hereby given that the Annual Meeting of Stockholders of Actinium Pharmaceuticals, Inc. will be held on Wednesday, November 18, 2020 at 9:30 a.m. EST at The Garden City Hotel, 45 Seventh Street, Garden City, NY 11530, for the following purposes:

Proposal 1: Election of two directors to serve as Class I directors on our Board of Directors until our 2023 Annual Meeting of Stockholders, or until their successors are elected and qualified or until their earlier resignation or removal;

Nominees:

01) David Nicholson 02) Richard I Steinhart

Proposal 2: To approve an amendment to the Actinium Pharmaceuticals’ Inc. 2019 Plan (the “2019 Plan”) to increase the total number of shares of common stock authorized for issuance under such plan from 333,333 by 2,750,000, to a total of 3,083,333 shares to attract and retain the best available personnel and to support planned hiring efforts as the company grows; and

Proposal 3: To ratify the appointment of Marcum LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2020.

This Proxy is solicited by the Board of Directors of Actinium Pharmaceuticals, Inc.,

which recommends a vote FOR Proposals 1, 2, and 3.

Material for this annual meeting and future meetings may be requested by one of the following methods:

2020 Annual Meeting of Stockholders to be held on November 18, 2020 at
the Garden City Hotel, 45 Seventh Street, Garden City, NY 11530

Have this notice available when you request a paper copy of the proxy materials or to vote your proxy electronically.

You must reference your control number to vote by Internet, telephone or request a paper copy of the proxy materials.

Your electronic vote authorizes the named proxies to vote your shares in the same manner
as if you marked, signed, dated and returned the proxy card.

☐	Preliminary Proxy Statement

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☐	Definitive Proxy Statement

☒	Definitive Additional Materials

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