0001567619-22-021900.txt : 20221221 0001567619-22-021900.hdr.sgml : 20221221 20221221091707 ACCESSION NUMBER: 0001567619-22-021900 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20221219 FILED AS OF DATE: 20221221 DATE AS OF CHANGE: 20221221 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Disbrow Joshua R. CENTRAL INDEX KEY: 0001566240 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 001-38247 FILM NUMBER: 221476682 MAIL ADDRESS: STREET 1: AMPIO PHARMACEUTICALS, INC. STREET 2: 5445 DTC PARKWAY, SUITE 925 CITY: GREENWOOD VILLAGE STATE: CO ZIP: 80111 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: AYTU BIOPHARMA, INC CENTRAL INDEX KEY: 0001385818 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 470883144 STATE OF INCORPORATION: DE FISCAL YEAR END: 0630 BUSINESS ADDRESS: STREET 1: 373 INVERNESS PARKWAY STREET 2: SUITE 206 CITY: ENGLEWOOD STATE: CO ZIP: 80112 BUSINESS PHONE: (720) 437-6580 MAIL ADDRESS: STREET 1: 373 INVERNESS PARKWAY STREET 2: SUITE 206 CITY: ENGLEWOOD STATE: CO ZIP: 80112 FORMER COMPANY: FORMER CONFORMED NAME: AYTU BIOSCIENCE, INC DATE OF NAME CHANGE: 20150609 FORMER COMPANY: FORMER CONFORMED NAME: AYTU BIOSCIENCE, INC. DATE OF NAME CHANGE: 20150609 FORMER COMPANY: FORMER CONFORMED NAME: Rosewind CORP DATE OF NAME CHANGE: 20070110 4 1 doc1.xml FORM 4 X0306 4 2022-12-19 0 0001385818 AYTU BIOPHARMA, INC AYTU 0001566240 Disbrow Joshua R. C/O AYTU BIOPHARMA, INC. 373 INVERNESS PARKWAY, SUITE 206 ENGLEWOOD CO 80112 1 1 0 0 Chief Executive Officer Common Stock 2022-12-19 4 P 0 112371 0.2229 A 1231877 D The purchase price reported above is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $0.213 to $0.23, inclusive. The reporting person undertakes to provide to AYTU Biopharma, Inc., any security holder of AYTU Biopharma, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges set forth in this footnote. Exhibit 24.1 Power of Attorney /s/ Mark Oki as attorney-in-fact for Joshua R. Disbrow 2022-12-20 EX-24.1 2 poa.htm POWER OF ATTORNEY POWER OF ATTORNEY 

LIMITED POWER OF ATTORNEY FOR REPORTING UNDER SECTION 16(a) OF THE
SECURITIES EXCHANGE ACT OF 1934, AS AMENDED

Know all by these presents, that the undersigned hereby constitutes and appoints
Jake Siciliano, Fei Gao and Mark Oki, each acting alone, as the undersigned's
true and lawful attorney-in-fact to:
(1)	execute for and on behalf of the undersigned, in the undersigned's capacity
as a director or officer of AYTU BioPharma, Inc., a Delaware corporation ("AYTU"),
Forms 3, 4 and 5 in accordance with Section 16(a) of the Securities Exchange
Exchange Act of 1934, as amended (the "Exchange Act"), and the rules
and regulations of the United States Securities and Exchange Commission ("SEC")
promulgated thereunder;
(2)	do and perform any and all acts for and on behalf of the undersigned which may be
necessary or desirable to complete and execute any such Forms 3, 4 and 5, complete and
execute any amendment or amendments thereto, and to timely file any such form with the
SEC and any stock exchange or similar authority, including completing and executing
a Uniform Application for Access Codes to File on Edgar on Form ID; and
(3) 	take any other action of any type whatsoever in connection with the foregoing which,
in the opinion of such attorney-in-fact, may be of benefit to, in the best interest of, or
legally required by, the undersigned, it being understood that the documents executed by such
attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in
such form and shall contain such terms and conditions as such attorney-in-fact may approve in
such attorney-in-fact's discretion.
The undersigned hereby grants to such attorney-in-fact full power and authority to do and
perform any and every act and thing whatsoever requisite, necessary, or proper to be done in
the exercise of the rights and powers herein granted, as fully to all intents and
purposes as the undersigned might or could do if personally present, with full power of
substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact
shall lawfully do or cause to be done by virtue of this power of attorney and the rights
and powers herein granted. The undersigned acknowledges that neither AYTU nor the
foregoing attorney-in-fact, in serving in such capacity at the request of the undersigned,
are not assuming any liability for the undersigned's responsibility to comply with the
requirements of Section 13 or Section 16 or the Exchange Act or Rule 144, any liability
of the undersigned for any failure to comply with such requirements, or any liability
of the undersigned for disgorgement of profits under Section 16(b) of the Exchange Act.
The undersigned agrees that each such attorney-in-fact herein may rely entirely on information
furnished orally or in writing by the undersigned to such attorney-in-fact. The undersigned
also agrees to indemnify and hold harmless AYTU and each such attorney-in-fact against
any losses, claims, damages or liabilities (or actions in these respects) that arise out of
or are based on any untrue statements or omission of necessary facts in the information
provided by the undersigned to such attorney-in-fact for purposes of executing,
acknowledging, delivering and filing Forms 3, 4 or 5 (including amendments thereto),
and agrees to reimburse AYTU and such attorney-in-fact for any legal or other expenses
reasonably incurred in connection with investigating or defending against any such loss,
claim, damage, liability or action.
This Power of Attorney supersedes any power of attorney previously executed by the undersigned
regarding the purposes outlined in the first paragraph hereof ("Prior Powers of Attorney"),
and the authority of the attorneys-in-fact named in any Prior Powers of Attorney is hereby
revoked.
This Power of Attorney shall remain in full force and effect until the undersigned is no
longer required to file Forms 3, 4 and 5 with respect to the undersigned's holdings of and
transactions in securities issued by AYTU, unless earlier revoked by the
undersigned in a signed writing delivered to the foregoing attorneys-in-fact.  This
Power of Attorney may be filed with the SEC as a confirming statement of authority
granted herein.

IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed
as of this 19th day of December, 2022.

/s/ Joshua Disbrow