OPIANT PHARMACEUTICALS, INC.

201 Santa Monica Boulevard, Suite 500

Santa Monica, California 90401

November 3, 2017

VIA EDGAR

United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, DC 20549-4561

Attn:    John Reynolds

Re:    Opiant Pharmaceuticals, Inc.

Registration Statement on Form S-3

File No. 333-220976    Filed October 13, 2017

Dear Mr. Reynolds:

Opiant Pharmaceuticals, Inc., a Delaware corporation (the “Company”), hereby requests that the effective date for the Registration Statement referred to above be accelerated so that it will be declared effective at 4:00 p.m. (EST) on November 7, 2017, or as soon as practicable thereafter, pursuant to Rule 461 of the Securities Act of 1933, as amended, unless we or our outside counsel, DLA Piper LLP (US), request by telephone that such Registration Statement be declared effective at some other time, pursuant to Rule 461 of the Securities Act of 1933, as amended.

The Company acknowledges that (i) should the United States Securities and Exchange Commission (the “Commission”) or the staff of the Commission, acting pursuant to delegated authority, declare the filing effective, such declaration does not foreclose the Commission from taking any action with respect to the filing; (ii) the action of the Commission or the staff of the Commission, acting pursuant to delegated authority, in declaring the filing effective, does not relieve the Company from its full responsibility for the adequacy and accuracy of the disclosure in the filing; and (iii) the Company may not assert staff comments and the declaration of effectiveness as a defense in any proceeding initiated by the Commission or any person under the federal securities laws of the United States.

Please contact David C. Schwartz of DLA Piper LLP (US) with any questions or comments at (973) 520-2555. Thank you for your assistance with this filing.

OPIANT PHARMACEUTICALS, INC.

By:     /s/ David O’Toole    

Name:    David O’Toole

Title:    Chief Financial Officer