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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 K54bSnttL3GiglsmjvjH1g==

<SEC-DOCUMENT>0001209191-10-034078.txt : 20100614
<SEC-HEADER>0001209191-10-034078.hdr.sgml : 20100614
<ACCEPTANCE-DATETIME>20100614170559
ACCESSION NUMBER:		0001209191-10-034078
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20100610
FILED AS OF DATE:		20100614
DATE AS OF CHANGE:		20100614

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Dewey Christopher C
		CENTRAL INDEX KEY:			0001385015

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33966
		FILM NUMBER:		10895481

	MAIL ADDRESS:	
		STREET 1:		120 BROADWAY
		STREET 2:		27TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10271

	FORMER NAME:	
		FORMER CONFORMED NAME:	Dewey Christopher
		DATE OF NAME CHANGE:	20070103

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MAKO Surgical Corp.
		CENTRAL INDEX KEY:			0001411861
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		IRS NUMBER:				201901148
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2555 DAVIE ROAD
		CITY:			FT. LAUDERDALE
		STATE:			FL
		ZIP:			33317
		BUSINESS PHONE:		954-927-2044

	MAIL ADDRESS:	
		STREET 1:		2555 DAVIE ROAD
		CITY:			FT. LAUDERDALE
		STATE:			FL
		ZIP:			33317
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-06-10</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001411861</issuerCik>
        <issuerName>MAKO Surgical Corp.</issuerName>
        <issuerTradingSymbol>MAKO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001385015</rptOwnerCik>
            <rptOwnerName>Dewey Christopher C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>BOX 23</rptOwnerStreet1>
            <rptOwnerStreet2>173 LAMINGTON ROAD</rptOwnerStreet2>
            <rptOwnerCity>OLDWICK</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08858</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Annual Director Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>12.87</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2010-06-10</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>3300</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2020-06-10</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>3300</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3300</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Vests and becomes exercisable ratably quarterly over one year commencing on the grant date.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Menashe R. Frank, attorney in fact</signatureName>
        <signatureDate>2010-06-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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