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Fair Value Measurements (Details) - USD ($)
$ in Thousands
Sep. 30, 2019
Dec. 31, 2018
Fair value measurements    
Restricted cash $ 603 $ 603
Headquarters and laboratory facilities, South San Francisco, lease signed April 2015    
Fair value measurements    
Restricted cash 603 603
Level I | Headquarters and laboratory facilities, South San Francisco, lease signed April 2015    
Fair value measurements    
Restricted cash 603 603
Level I | Money market funds    
Fair value measurements    
Financial assets 94,600 76,600
Overnight repurchase agreements | Level II    
Fair value measurements    
Cash and and cash equivalents, fair value $ 100,000 $ 0