October 25, 2011

VIA EDGAR TRANSMISSION

Securities and Exchange Commission

Judiciary Plaza

100 F Street, NE

Washington, DC  20549

Attn: Vincent J. DiStefano

Re:  Hatteras Multi-Strategy Institutional Fund, L.P. (the “Registrant”)

File Nos. 333-176639; 811-21986

Ladies and Gentlemen:

Enclosed is a request of the Registrant and its principal underwriter for acceleration of the Registrant’s Registration Statement on Form N-2, and Pre-Effective Amendment No. 1 thereto, under the Securities Act of 1933, as amended, and of Amendment No. 7 to the Registrant’s Registration Statement on Form N-2 under the Investment Company Act of 1940, as amended. Please contact me at (215) 988-2972 with any questions related to this request and to notify of the effectiveness of the Registration Statement. In my absence, please contact Joshua B. Deringer, Esq., at (215) 988-2959.

Sincerely,

/s/ Joseph B. Andolina

Joseph B. Andolina

Enclosure