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Equity Incentive Plans, Employee Stock Purchase Plan and Stock-Based Compensation - Additional Information (Details) - USD ($)
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Sep. 26, 2018
Sep. 25, 2018
Aug. 31, 2019
Feb. 28, 2017
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Jan. 01, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Reserved common stock         10,674,126   10,674,126   8,331,103  
Aggregate intrinsic value of stock options exercised         $ 300,000 $ 5,000 $ 2,200,000 $ 81,000    
Weighted-average estimated grant-date fair value of employee stock options granted         $ 12.84 $ 5.60 $ 14.71 $ 5.03    
Share-based compensation arrangement by share-based payment award options, shares granted             266,724   266,724  
Stock-based compensation expense         $ 5,907,000 $ 3,011,000 $ 9,859,000 $ 5,718,000    
Liability attributable to call option plan         $ 137,000   $ 137,000   $ 109,000  
Restricted Stock Units                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Restricted common stock granted             1,511,750      
Shares vesting period             4 years      
2018 Equity Incentive Plan                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Reserved common stock   2,300,000                
Annual increase period of common stock reserved for issuance   10 years                
Maximum number of shares issuable                   2,287,605
Shares available for grant         1,555,985   1,555,985      
2018 Equity Incentive Plan | Restricted Stock Units                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Total unrecognized compensation cost related to unvested granted         $ 32,500,000 6,200,000 $ 32,500,000 $ 6,200,000    
Remaining unrecognized compensation cost expected to be recognized over weighted-average period             3 years 6 months 2 years 9 months 18 days    
2018 Equity Incentive Plan | Employee Stock Options                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Total unrecognized compensation cost related to unvested granted         27,500,000 20,100,000 $ 27,500,000 $ 20,100,000    
Remaining unrecognized compensation cost expected to be recognized over weighted-average period             2 years 7 months 6 days 2 years 7 months 6 days    
2018 Equity Incentive Plan | Employee Stock Purchase Plan                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Unrecognized stock-based compensation expense         $ 100,000 100,000 $ 100,000 $ 100,000    
2018 Equity Incentive Plan | Maximum                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Increase in stock reserved for issuance as percentage of capital stock outstanding on last day of preceding year   5.00%                
2018 Employee Stock Purchase Plan                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Reserved common stock 230,000                  
Annual increase period of common stock reserved for issuance 10 years                  
Increase in stock reserved for issuance as percentage of capital stock outstanding on last day of preceding year 1.00%                  
Maximum number of shares issuable 2,300,000       725,714   725,714      
Shares available for grant         421,277   421,277      
Shares available for grant, increase                   457,521
Call Option Plan                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Stock-based compensation expense         $ 26,000 64,000 $ 46,000 68,000    
Other income (expense)         $ (12,000) $ (1,800,000) $ 18,000 $ (2,000,000.0)    
Call Option Plan | Option Granted in February 2017                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Share-based compensation arrangement by share-based payment award options, shares granted       248,944            
Call options expiration period       1 year            
Call Option Plan | Option Granted in February 2017 | January 1 , 2017                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Call options vesting percentage       25.00%            
Call Option Plan | Option Granted in February 2017 | January 1 , 2018                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Call options vesting percentage       25.00%            
Call Option Plan | Option Granted in February 2017 | January 1 , 2019                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Call options vesting percentage       25.00%            
Call Option Plan | Option Granted in February 2017 | January 1 , 2020                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Call options vesting percentage       25.00%            
Call Option Plan | Option Granted in August 2019                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Share-based compensation arrangement by share-based payment award options, shares granted     17,780              
Call options expiration period     1 year              
Call Option Plan | Option Granted in August 2019 | January 1 , 2019                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Call options vesting percentage     25.00%              
Call Option Plan | Option Granted in August 2019 | January 1 , 2020                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Call options vesting percentage     25.00%              
Call Option Plan | Option Granted in August 2019 | January 1 , 2021                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Call options vesting percentage     25.00%              
Call Option Plan | Option Granted in August 2019 | January 1 , 2022                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Call options vesting percentage     25.00%              
Call Option Plan | Vaxcyte, Inc.                    
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                    
Reserved common stock         266,724   266,724