Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash Flows from Operating Activities
Net loss	$ (72,185)	$ (61,967)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	15,927	12,740
Operating lease right-of-use asset amortization	1,168	1,168
(Accretion) amortization of discount/premium on marketable securities	(2,215)	454
Depreciation	485	508
Other	194
Changes in operating assets and liabilities:
Receivable from collaboration partner	(29)	1,523
Prepaid expenses and other assets	2,211	(255)
Accounts payable	933	(184)
Payable to collaboration partner	(59)	(819)
Accrued expenses and other payables	(5,661)	(1,553)
Deferred revenue		(1,601)
Operating lease liability	(1,354)	(1,315)
Net cash used in operating activities	(60,585)	(51,301)
Cash Flows from Investing Activities
Purchase of marketable securities	(34,122)	(102,121)
Proceeds from maturities of marketable securities	69,896	132,942
Purchases of property and equipment	(186)	(563)
Net cash provided by investing activities	35,588	30,258
Cash Flows from Financing Activities
Proceeds from public offering of common stock, net of issuance costs	107,868
Proceeds from at-the-market offering, net of issuance costs	24,302	14,553
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan	3,234	3,213
Tax withholding payments related to net settlement of restricted stock units	(769)	(186)
Issuance costs related to prior period common stock offering		25
Net cash provided by financing activities	134,635	17,605
Effect of exchange rate changes on cash, cash equivalents and restricted cash		10
Net increase (decrease) in cash, cash equivalents and restricted cash	109,638	(3,428)
Cash, cash equivalents and restricted cash, beginning of period	125,969	123,890
Cash, cash equivalents and restricted cash, end of period	235,607	120,462
Supplemental Disclosure of Non-Cash Financing and Investing Information:
Purchases of property and equipment in accounts payable and accrued liabilities	61	$ 122
Issuance costs related to common stock offering included in accrued liabilities and other payables	$ 78