Consolidated Statements of Operations and Comprehensive Loss (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Revenue:
Net product revenue	$ 35,864	$ 30,411	$ 19,069
Contract revenue	8,462	7,165	4,373
Total revenue	44,326	37,576	23,442
Operating expenses:
Cost of sales	19,496	19,293	12,846
Royalty expense	1,353	1,205	843
Research and development	21,414	33,043	28,643
Selling, general and administrative	49,494	60,459	51,270
Total operating expenses	91,757	114,000	93,602
Loss from operations	(47,431)	(76,424)	(70,160)
Other income (expense):
Interest income	53	37	5
Interest expense	(10,313)	(7,644)	(10,013)
Change in fair value of warrant liability	11,811	445	6,725
Change in fair value of embedded derivatives	(147)	(240)	0
Other expense	(1,354)	(86)	(111)
Total other income (expense)	50	(7,488)	(3,394)
Loss before income taxes	(47,381)	(83,912)	(73,554)
Provision for income tax benefit (expense)	(5)	9	(10)
Net loss	(47,386)	(83,903)	(73,564)
Net loss per share, basic and diluted, USD per share	$ (0.59)	$ (1.96)	$ (17.63)
Weighted average shares outstanding, basic and diluted, in shares	80,558	42,712	4,173
Comprehensive loss	$ (47,386)	$ (83,903)	$ (73,564)