Collaboration, License and Purchase Agreements - Narrative (Detail) (USD $)	12 Months Ended			0 Months Ended		12 Months Ended	1 Months Ended		3 Months Ended	12 Months Ended				1 Months Ended				12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010	Nov. 02, 2012 Alkermes Commerical Manufacturing And Supply Agreement [Member]	Jul. 06, 2012 Mallinckrodt LLC Co-Promotion Agreement [Member]	Dec. 31, 2012 Mallinckrodt LLC Co-Promotion Agreement [Member]	Aug. 31, 2012 Astellas Pharma Us Inc Co Promotion Agreement [Member]	Jul. 31, 2009 Astellas Pharma Us Inc Co Promotion Agreement [Member]	Mar. 31, 2012 Astellas Pharma Us Inc Co Promotion Agreement [Member]	Dec. 31, 2012 Astellas Pharma Us Inc Co Promotion Agreement [Member] tail_payments	Dec. 31, 2011 Astellas Pharma Us Inc Co Promotion Agreement [Member]	Dec. 31, 2010 Astellas Pharma Us Inc Co Promotion Agreement [Member]	Dec. 20, 2011 Astellas Pharma Us Inc Co Promotion Agreement [Member]	Jul. 31, 2009 Astellas Pharma Us Inc Co Promotion Agreement [Member] Minimum [Member]	Jul. 31, 2009 Astellas Pharma Us Inc Co Promotion Agreement [Member] Maximum [Member]	Feb. 28, 2010 Aradigm Corporation Asset Purchase Agreement [Member]	Aug. 31, 2006 Aradigm Corporation Asset Purchase Agreement [Member]	Dec. 31, 2012 Aradigm Corporation Asset Purchase Agreement [Member]	Dec. 31, 2011 Aradigm Corporation Asset Purchase Agreement [Member]	Dec. 31, 2010 Aradigm Corporation Asset Purchase Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Monthly forecast period				18 months
Annual forecast period				3 years
Order period after forecast submission				4 months
Percentage required to purchase				75.00%
Percentage to be purchased from supplier				100.00%
Agreement renewal period					6 months
Sales period for tail payment					12 months
Agreement termination notice period					60 days
Incurred service fee expenses						$ 161,000				$ 1,756,000	$ 6,657,000	$ 3,660,000
Non-refundable up-front payment								2,000,000
Milestone payments								18,000,000
Service fee rate														45.00%	55.00%
Deferred agreement payments								20,000,000
Contract revenue									8,462,000
Amortizing the upfront and milestone payments as contract revenue recognized										8,462,000	7,165,000	4,373,000
Number of annual tail payments										2
Annual tail payment liability							742,000			2,795,000	4,016,000		5,291,000
Interest expense										550,000
Service fee reduction							1,500,000
Present value of the service fee receivable and tail payment										1,924,000
Recognized shared marketing expense										253,000	1,663,000	3,853,000
Payment to acquire tangible and intangible assets																	4,000,000
Milestone payment to acquire tangible and intangible assets																4,000,000
Royalty rate																	3.00%
Royalty expense	1,353,000	1,205,000	843,000															1,353,000	1,205,000	843,000
Expected amortization expense, next twelve months																		286,000
Expected amortization expense, year two																		286,000
Expected amortization expense, year three																		286,000
Expected amortization expense, year four																		286,000
Expected amortization expense, year five																		286,000
Expected amortization expense, after year five																		$ 1,714,000