CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Net product sales	$ 74,740	$ 9,587	$ 0
Collaboration revenue	6,950	4,056	3,648
Total revenues	81,690	13,643	3,648
Operating costs and expenses:
Cost of product sales (excluding intangible asset amortization)	4,834	542	0
Research and development	142,659	138,002	115,639
Selling, general and administrative	148,524	99,574	60,792
Intangible asset amortization	7,885	3,942	0
Acquired in-process research and development and related costs	0	10,700	251,438
Change in fair value of contingent consideration	1,885	8,600	5,600
Total operating expenses	305,787	261,360	433,469
Loss from operations	(224,097)	(247,717)	(429,821)
Other income (expense):
Interest income	659	2,891	9,804
Interest expense	(15,276)	(3,759)	(2)
Other income, net	11,406	21,777	516
Loss from operations before income taxes	(227,308)	(226,808)	(419,503)
Income tax expense (benefit)	105	(17,425)	0
Net loss	$ (227,413)	$ (209,383)	$ (419,503)
Net loss per share, basic (in dollars per share)	$ (4.07)	$ (3.90)	$ (9.74)
Net loss per share, diluted (in dollars per share)	$ (4.07)	$ (3.90)	$ (9.74)
Weighted average common shares outstanding, basic (in shares)	55,880	53,706	43,078
Weighted average common shares outstanding, diluted (in shares)	55,880	53,706	43,078