Strategic License Agreements (Details) $ in Thousands		1 Months Ended		12 Months Ended
	Sep. 26, 2019 USD ($) institution	Feb. 28, 2022 USD ($)	Oct. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and development expense				$ 0	$ 10,700	$ 251,437
Universities Of Antwerp And Leuven In Belgium (The Universities) And Amendment Fee | Strategic license agreement
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
One-time amendment fee			$ 7,000
Future regulatory and sales-based milestones payable rate (percent)			15.00%
Refund liability				7,000
Universities Of Antwerp And Leuven In Belgium (The Universities) And Amendment Fee | Strategic license agreement | Subsequent Event
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Payment of one-time payment due for collaboration activities		$ 7,000
Columbia University
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Amounts due or accrued				0	0
Two other research institutions
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of research institutions party to license agreement | institution	2
Amounts due or accrued				0	0
Tevard Biosciences
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Option agreement, amount paid					5,500	$ 2,000
Collaboration agreement consideration					5,200
Promissory notes purchased				$ 5,000	5,000
Advance notice needed				180 days
Collaboration agreement, upfront payment					10,200
In progress research and development				$ 5,200
Research and development expense				$ 3,500	$ 700
Tevard Biosciences | Convertible Note Receivable
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Interest rate (percent)					3.50%
Tevard Biosciences | Maximum
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Additional milestone payments					$ 100,000
Modis Acquisition
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expiration period of license agreement following first bona fide sale of licensed product	15 years
Upon Achievement of Regulatory Milestones | Modis Acquisition | Columbia University
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent payment under license agreement	$ 2,900
Upon Achievement of Certain Commercial Milestone Events | Two other research institutions
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent payment under license agreement	10,000
Upon Achievement of Certain Commercial Milestone Events | Modis Acquisition | Columbia University
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent payment under license agreement	25,000
Upon Achievement of Research, Development and Regulatory Milestone | Two other research institutions
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent payment under license agreement	$ 3,000