Revenues - Narrative (Details)	12 Months Ended			22 Months Ended
	Dec. 31, 2021 USD ($) representative	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Dec. 31, 2020 USD ($)	Mar. 31, 2019 USD ($)
Disaggregation of Revenue [Line Items]
Net product sales	$ 74,740,000	$ 9,587,000	$ 0
Number of joint steering committee (JSC) representatives | representative	3
Written notice period to the other party	1 year
Total transaction price	$ 23,000,000
Deferred revenue	$ 8,300,000
Revenue recognized				$ 0
U.S. Customer | Revenue | Customer Concentration Risk
Disaggregation of Revenue [Line Items]
Concentration percentage (percent)	88.00%	100.00%
Fixed-price Contract
Disaggregation of Revenue [Line Items]
Payment due for collaborative agreement	$ 20,000,000				$ 20,000,000
Variable Consideration Priced Contract
Disaggregation of Revenue [Line Items]
Payment due for collaborative agreement	3,000,000
Variable Consideration Priced Contract | Upon Achievement of Regulatory Milestones
Disaggregation of Revenue [Line Items]
Additional amount that can be earned upon achievement of regulatory milestones	66,000,000
Variable Consideration Priced Contract | Upon Achievement of Net Sales Milestones
Disaggregation of Revenue [Line Items]
Additional amounts that could be earned by achievement of net sales milestones	$ 42,500,000