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Stock-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2021
Share-based Payment Arrangement [Abstract]  
Schedule of Stock Options Activity
The following table summarizes our stock option activity for the year ended December 31, 2021:
Shares
(in thousands)
Weighted
Average
Exercise
Price
Weighted
Average
Remaining
Contractual
Term (years)
Aggregate
Intrinsic
Value
(in thousands)
Outstanding at December 31, 20205,311 $29.12 
Granted1,833 17.79 
Exercised(58)10.08 
Canceled(401)28.71 
Outstanding at December 31, 20216,685 $26.20 6.9$7,926 
Exercisable at December 31, 20214,101 $27.00 5.7$7,232 
Schedule of Restricted Stock Units Activity The following table summarizes our stock unit awards activity for the year ended December 31, 2021:
RSUsPSUs
Shares
(in thousands)
Weighted Average
Grant Date
Fair Value
Shares
(in thousands)
Weighted Average
Grant Date
Fair Value
Nonvested at December 31, 2020393 $37.68 — $— 
Granted616 17.66 494 19.53 
Vested(144)39.98 (152)19.85 
Canceled(61)25.24 (42)19.99 
Nonvested at December 31, 2021804 $22.85 300 $19.30 
Assumptions used in the Black-Scholes Option-Pricing Model A summary of the assumptions used to estimate the fair values of stock option grants for the years presented is as follows:
 Year Ended December 31,
 202120202019
Risk free interest rate
0.5% to 1.4%
0.3% to 1.8%
1.4% to 2.6%
Expected term
5.3 to 6.1 years
5.3 to 6.1 years
5.3 to 6.1 years
Expected volatility
70.0% to 73.7%
73.2% to 76.7%
73.5% to 82.3%
Expected dividend yield—%—%—%
Weighted-average fair value of option on grant date$11.36$17.86$32.64
Stock-Based Compensation Expense
The following table summarizes the components of total stock-based compensation expense included in the consolidated statements of operations for the periods presented:
 Year Ended December 31,
(In thousands)202120202019
Research and development12,962 12,139 8,293 
Selling, general and administrative22,501 17,037 12,954 
Total$35,463 $29,176 $21,247 
Stock-based compensation of $1.0 million was capitalized into inventory for the year ended December 31, 2021.